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- W2110503997 abstract "Background Although elevated serum concentrations of γ-glutamyltrans- ferase (GGT) or alanine aminotransferase (ALT) have been associated with type 2 diabetes mellitus, it is unclear whether each is an independent predictor of type 2 diabetes or merely a surrogate marker for fatty liver or hepatic injury. Methods We assessed clinical and laboratory findings in 3556 non-diabetic subjects (2217 men, 1339 women; age, 45.7 ± 8.1 (range 20–79) years) without fatty liver or clinically significant hepatic dysfunction who underwent voluntary medical check-ups at a 5-year interval. Results The odds ratio of developing type 2 diabetes increased significantly with increasing GGT and ALT levels at baseline. In multiple logistic regression models adjusted for age, sex, alcohol consumption, smoking, body mass index (BMI), triglycerides, high-density lipoprotein (HDL)-cholesterol, fasting glucose, and ALT, the highest quartile of GGT remained significantly associated with type 2 diabetes. Compared with the first GGT quartile, the odds ratios of the second, third, and fourth GGT quartiles were 0.64 (95% CI, 0.25–1.65), 1.12 (0.45–2.78), and 3.07 (1.21–7.76), respectively. The adjusted odds ratios for the second, third, and fourth ALT quartiles in the same logistic regression model were 2.40 (0.83–6.94), 2.85 (1.03–7.90), and 4.31 (1.56–11.88), respectively. The risk of type 2 diabetes was additive with respect to GGT and ALT quartiles. Conclusions Increased serum GGT and ALT levels are independent, additive risk factors for the development of type 2 diabetes mellitus in subjects without fatty liver or hepatic dysfunction. Copyright © 2008 John Wiley & Sons, Ltd." @default.
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- W2110503997 date "2009-01-01" @default.
- W2110503997 modified "2023-09-26" @default.
- W2110503997 title "Association of serum γ-glutamyltransferase and alanine aminotransferase activities with risk of type 2 diabetes mellitus independent of fatty liver" @default.
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- W2110503997 doi "https://doi.org/10.1002/dmrr.890" @default.
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