FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110508537> ?p ?o ?g. }

• W2110508537 endingPage "8" @default.
• W2110508537 startingPage "473" @default.
• W2110508537 abstract "Neuroblastoma (NB) is a high risk tumor of childhood, and raised serum ferritin is an adverse prognostic factor. The hypothesis that iron chelation therapy impacts tumor status and patient prognosis through changes in iron metabolism has been systematically evaluated here in a xenograft model of human NB. One of two iron chelators was given in seven different regimens to nude mice xenografted s.c. with either IMR-32, an established cell line, or JBN-1, heterotransplanted directly from a patient. Nude mice (a total of 160 in 24 cohorts) were given: desferrioxamine (DFO) by s.c. bolus or reservoir; 1,2-dimethyl-3-hydroxypyridin-4-one (L1), i.p. or orally; or saline. Measurements of mean Hb and liver iron levels were compared with corresponding saline cohorts per regimen as well as for pooled cohorts per agent for both cell lines. For IMR-32 xenografts, significant differences in Hb were achieved with L1 (10.9 g/dl pooled versus 13.7 g/dl controls) and in liver iron with DFO and L1 (235 microg/g and 306 microg/g, respectively, versus 520 microg/g). For JBN-1, the pattern was similar. With L1, H6 was 10.2 g/dl and controls were 11.7 g/dl (individual DFO cohorts were also significant); liver iron with DFO was 303 microg/g, liver iron with L1 was 270 microg/g, and controls were 387 microg/g. Additional therapy prior to tumor injection (67 mice and 10 cohorts) did not increase the depletion. Despite documentation of iron depletion, no reductions in tumor engraftment, latency, or tumor size at end point were achieved in the chelator-treated mice, compared with controls populations. Accordingly, inclusion of these iron chelators in clinical trials for NB appears unwarranted." @default.
• W2110508537 created "2016-06-24" @default.
• W2110508537 creator A5000857657 @default.
• W2110508537 creator A5007702427 @default.
• W2110508537 creator A5052864521 @default.
• W2110508537 creator A5058636384 @default.
• W2110508537 creator A5062634358 @default.
• W2110508537 creator A5063697056 @default.
• W2110508537 date "1998-02-01" @default.
• W2110508537 modified "2023-09-27" @default.
• W2110508537 title "Failure of iron chelators to reduce tumor growth in human neuroblastoma xenografts." @default.
• W2110508537 cites W103079393 @default.
• W2110508537 cites W1520047720 @default.
• W2110508537 cites W1564880933 @default.
• W2110508537 cites W1871616831 @default.
• W2110508537 cites W1945844778 @default.
• W2110508537 cites W1974905040 @default.
• W2110508537 cites W1977006817 @default.
• W2110508537 cites W1993448480 @default.
• W2110508537 cites W1993488925 @default.
• W2110508537 cites W1994064082 @default.
• W2110508537 cites W2023607117 @default.
• W2110508537 cites W2027016374 @default.
• W2110508537 cites W2032088197 @default.
• W2110508537 cites W2036228109 @default.
• W2110508537 cites W2043074030 @default.
• W2110508537 cites W2059005982 @default.
• W2110508537 cites W2067900214 @default.
• W2110508537 cites W2070810920 @default.
• W2110508537 cites W2119272726 @default.
• W2110508537 cites W2119397834 @default.
• W2110508537 cites W2123345036 @default.
• W2110508537 cites W2146449631 @default.
• W2110508537 cites W2149397803 @default.
• W2110508537 cites W2155127143 @default.
• W2110508537 cites W2169013600 @default.
• W2110508537 cites W2214504204 @default.
• W2110508537 cites W2253810935 @default.
• W2110508537 cites W2312723416 @default.
• W2110508537 cites W2400973399 @default.
• W2110508537 cites W2414777429 @default.
• W2110508537 cites W244409642 @default.
• W2110508537 cites W30168135 @default.
• W2110508537 cites W1567707644 @default.
• W2110508537 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9458092" @default.
• W2110508537 hasPublicationYear "1998" @default.
• W2110508537 type Work @default.
• W2110508537 sameAs 2110508537 @default.
• W2110508537 citedByCount "15" @default.
• W2110508537 countsByYear W21105085372012 @default.
• W2110508537 countsByYear W21105085372013 @default.
• W2110508537 countsByYear W21105085372015 @default.
• W2110508537 countsByYear W21105085372016 @default.
• W2110508537 countsByYear W21105085372018 @default.
• W2110508537 crossrefType "journal-article" @default.
• W2110508537 hasAuthorship W2110508537A5000857657 @default.
• W2110508537 hasAuthorship W2110508537A5007702427 @default.
• W2110508537 hasAuthorship W2110508537A5052864521 @default.
• W2110508537 hasAuthorship W2110508537A5058636384 @default.
• W2110508537 hasAuthorship W2110508537A5062634358 @default.
• W2110508537 hasAuthorship W2110508537A5063697056 @default.
• W2110508537 hasConcept C126322002 @default.
• W2110508537 hasConcept C197934379 @default.
• W2110508537 hasConcept C2776715637 @default.
• W2110508537 hasConcept C2777397205 @default.
• W2110508537 hasConcept C2778319317 @default.
• W2110508537 hasConcept C43376680 @default.
• W2110508537 hasConcept C54355233 @default.
• W2110508537 hasConcept C71924100 @default.
• W2110508537 hasConcept C81885089 @default.
• W2110508537 hasConcept C86803240 @default.
• W2110508537 hasConcept C90924648 @default.
• W2110508537 hasConceptScore W2110508537C126322002 @default.
• W2110508537 hasConceptScore W2110508537C197934379 @default.
• W2110508537 hasConceptScore W2110508537C2776715637 @default.
• W2110508537 hasConceptScore W2110508537C2777397205 @default.
• W2110508537 hasConceptScore W2110508537C2778319317 @default.
• W2110508537 hasConceptScore W2110508537C43376680 @default.
• W2110508537 hasConceptScore W2110508537C54355233 @default.
• W2110508537 hasConceptScore W2110508537C71924100 @default.
• W2110508537 hasConceptScore W2110508537C81885089 @default.
• W2110508537 hasConceptScore W2110508537C86803240 @default.
• W2110508537 hasConceptScore W2110508537C90924648 @default.
• W2110508537 hasIssue "3" @default.
• W2110508537 hasLocation W21105085371 @default.
• W2110508537 hasOpenAccess W2110508537 @default.
• W2110508537 hasPrimaryLocation W21105085371 @default.
• W2110508537 hasRelatedWork W1966794953 @default.
• W2110508537 hasRelatedWork W1968089154 @default.
• W2110508537 hasRelatedWork W1983597965 @default.
• W2110508537 hasRelatedWork W2005407517 @default.
• W2110508537 hasRelatedWork W2023352512 @default.
• W2110508537 hasRelatedWork W2030140599 @default.
• W2110508537 hasRelatedWork W2060771608 @default.
• W2110508537 hasRelatedWork W2067848156 @default.
• W2110508537 hasRelatedWork W2162632888 @default.
• W2110508537 hasRelatedWork W2642189066 @default.
• W2110508537 hasVolume "58" @default.

• next