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- W2110531858 endingPage "49" @default.
- W2110531858 startingPage "35" @default.
- W2110531858 abstract "Inhibin and activin are members of the transforming growth factor beta (TGFbeta) family of cytokines produced by the gonads, with a recognised role in regulating pituitary FSH secretion. Inhibin consists of two homologous subunits, alpha and either betaA or betaB (inhibin A and B). Activins are hetero- or homodimers of the beta-subunits. Inhibin and free alpha subunit are known products of two ovarian tumours (granulosa cell tumours and mucinous carcinomas). This observation has provided the basis for the development of a serum diagnostic test to monitor the occurrence and treatment of these cancers. Transgenic mice with an inhibin alpha subunit gene deletion develop stromal/granulosa cell tumours suggesting that the alpha subunit is a tumour suppressor gene. The role of inhibin and activin is reviewed in ovarian cancer both as a measure of proven clinical utility in diagnosis and management and also as a factor in the pathogenesis of these tumours. In order to place these findings into perspective the biology of inhibin/activin and of other members of the TGFbeta superfamily is also discussed." @default.
- W2110531858 created "2016-06-24" @default.
- W2110531858 creator A5008205881 @default.
- W2110531858 creator A5046419066 @default.
- W2110531858 creator A5049062447 @default.
- W2110531858 date "2004-03-01" @default.
- W2110531858 modified "2023-10-03" @default.
- W2110531858 title "Inhibin/activin and ovarian cancer." @default.
- W2110531858 cites W1574602960 @default.
- W2110531858 cites W1636022999 @default.
- W2110531858 cites W1923939500 @default.
- W2110531858 cites W1954207676 @default.
- W2110531858 cites W1965772308 @default.
- W2110531858 cites W1966596967 @default.
- W2110531858 cites W1969041157 @default.
- W2110531858 cites W1970500106 @default.
- W2110531858 cites W1977803299 @default.
- W2110531858 cites W1979438376 @default.
- W2110531858 cites W1985533709 @default.
- W2110531858 cites W1991046191 @default.
- W2110531858 cites W1993800649 @default.
- W2110531858 cites W1997702431 @default.
- W2110531858 cites W2005080322 @default.
- W2110531858 cites W2007019698 @default.
- W2110531858 cites W2008627153 @default.
- W2110531858 cites W2009823022 @default.
- W2110531858 cites W2011377754 @default.
- W2110531858 cites W2014753559 @default.
- W2110531858 cites W2016068055 @default.
- W2110531858 cites W2018564056 @default.
- W2110531858 cites W2019474025 @default.
- W2110531858 cites W2019998854 @default.
- W2110531858 cites W2028946225 @default.
- W2110531858 cites W2029131356 @default.
- W2110531858 cites W2030462220 @default.
- W2110531858 cites W2030735054 @default.
- W2110531858 cites W2030772846 @default.
- W2110531858 cites W2033162087 @default.
- W2110531858 cites W2034427531 @default.
- W2110531858 cites W2035066075 @default.
- W2110531858 cites W2036509369 @default.
- W2110531858 cites W2037673347 @default.
- W2110531858 cites W2037917812 @default.
- W2110531858 cites W2041889805 @default.
- W2110531858 cites W2043215244 @default.
- W2110531858 cites W2043402708 @default.
- W2110531858 cites W2047823718 @default.
- W2110531858 cites W2048142190 @default.
- W2110531858 cites W2051236876 @default.
- W2110531858 cites W2052745112 @default.
- W2110531858 cites W2055569553 @default.
- W2110531858 cites W2060111268 @default.
- W2110531858 cites W2061064143 @default.
- W2110531858 cites W2061758394 @default.
- W2110531858 cites W2069117573 @default.
- W2110531858 cites W2069509517 @default.
- W2110531858 cites W2069726225 @default.
- W2110531858 cites W2071745366 @default.
- W2110531858 cites W2084294723 @default.
- W2110531858 cites W2085131417 @default.
- W2110531858 cites W2085269651 @default.
- W2110531858 cites W2090541124 @default.
- W2110531858 cites W2091317757 @default.
- W2110531858 cites W2091334062 @default.
- W2110531858 cites W2103073411 @default.
- W2110531858 cites W2106089380 @default.
- W2110531858 cites W2107141278 @default.
- W2110531858 cites W2111357517 @default.
- W2110531858 cites W2115190185 @default.
- W2110531858 cites W2117322257 @default.
- W2110531858 cites W2117542108 @default.
- W2110531858 cites W2124541440 @default.
- W2110531858 cites W2131211068 @default.
- W2110531858 cites W2137463644 @default.
- W2110531858 cites W2137892755 @default.
- W2110531858 cites W2143703336 @default.
- W2110531858 cites W2143877282 @default.
- W2110531858 cites W2145870562 @default.
- W2110531858 cites W2146304893 @default.
- W2110531858 cites W2147612074 @default.
- W2110531858 cites W2149414351 @default.
- W2110531858 cites W2162305823 @default.
- W2110531858 cites W2163802459 @default.
- W2110531858 cites W2165769086 @default.
- W2110531858 cites W2317608410 @default.
- W2110531858 cites W2342433155 @default.
- W2110531858 cites W2409456257 @default.
- W2110531858 cites W2411951247 @default.
- W2110531858 cites W2418448471 @default.
- W2110531858 cites W2615946525 @default.
- W2110531858 cites W2906772903 @default.
- W2110531858 cites W68131063 @default.
- W2110531858 cites W91424267 @default.
- W2110531858 cites W2135103256 @default.
- W2110531858 doi "https://doi.org/10.1677/erc.0.0110035" @default.
- W2110531858 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15027884" @default.
- W2110531858 hasPublicationYear "2004" @default.
- W2110531858 type Work @default.