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• W2110535287 abstract "The specification of cell fate is critical for proper cell differentiation and organogenesis. In endocrine tissues, this process leads to the differentiation, often a multistep process, of hormone-producing cells. This process is driven by a combination of transcription factors (TFs) that includes general factor, tissue-restricted, and/or cell-restricted factors. The last 2 decades have seen the discovery of many TFs of restricted expression and function in endocrine tissues. These factors are typically critical for expression of hormone-coding genes as well as for differentiation and proper function of hormone-producing cells. Further, genes encoding these tissue-restricted TFs are themselves subject to mutations that cause hormone deficiencies. Although the model that emerged from these 2 decades is one in which a specific combination of TFs drives a unique cell specification and genetic program, recent findings have led to the discovery of TFs that have the unique property of being able to remodel chromatin and thus modify the epigenome. Most importantly, such factors, known as pioneer TFs, appear to play critical roles in programming the epigenome during the successive steps involved in cell specification. This review summarizes our current understanding of the mechanisms for pioneer TF remodeling of chromatin. Currently, very few TFs that have proven pioneer activity are known, but it will be critical to identify these factors and understand their mechanisms of action if we are to harness the potential of regenerative therapies in endocrinology." @default.
• W2110535287 created "2016-06-24" @default.
• W2110535287 creator A5043343859 @default.
• W2110535287 date "2014-07-01" @default.
• W2110535287 modified "2023-10-14" @default.
• W2110535287 title "Minireview: Pioneer Transcription Factors in Cell Fate Specification" @default.
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• W2110535287 cites W1968345969 @default.
• W2110535287 cites W1968931043 @default.
• W2110535287 cites W1972532453 @default.
• W2110535287 cites W1973528487 @default.
• W2110535287 cites W1974767234 @default.
• W2110535287 cites W1978125302 @default.
• W2110535287 cites W1979513200 @default.
• W2110535287 cites W1982327008 @default.
• W2110535287 cites W1983238320 @default.
• W2110535287 cites W1986586739 @default.
• W2110535287 cites W1992049566 @default.
• W2110535287 cites W1998000745 @default.
• W2110535287 cites W2002262418 @default.
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• W2110535287 cites W2010790480 @default.
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• W2110535287 doi "https://doi.org/10.1210/me.2014-1084" @default.
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