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• W2110542485 endingPage "489" @default.
• W2110542485 startingPage "479" @default.
• W2110542485 abstract "•Recombination between phages CTX and RS1, and point mutations in the cholera toxin gene ctxB, generate new CTXs. •Population shift in Vibrio cholerae is accompanied by a change in CTX, particularly in the gene ctxB. •V. cholerae uses a genetic mechanism to replace an old CTX with a new CTX. •Population shifts in V. cholerae might be caused by changes in existing immunity. •Understanding the selection of a particular strain will help us to combat cholera. The analysis of the whole-genome sequences of Vibrio cholerae strains from previous and current cholera pandemics has demonstrated that genomic changes and alterations in phage CTX (particularly in the gene encoding the B subunit of cholera toxin) were major features in the evolution of V. cholerae. Recent studies have revealed the genetic mechanisms in these bacteria by which new variants of V. cholerae are generated from type-specific strains; these mechanisms suggest that certain strains are selected by environmental or human factors over time. By understanding the mechanisms and driving forces of historical and current changes in the V. cholerae population, it would be possible to predict the direction of such changes and the evolution of new variants; this has implications for the battle against cholera. The analysis of the whole-genome sequences of Vibrio cholerae strains from previous and current cholera pandemics has demonstrated that genomic changes and alterations in phage CTX (particularly in the gene encoding the B subunit of cholera toxin) were major features in the evolution of V. cholerae. Recent studies have revealed the genetic mechanisms in these bacteria by which new variants of V. cholerae are generated from type-specific strains; these mechanisms suggest that certain strains are selected by environmental or human factors over time. By understanding the mechanisms and driving forces of historical and current changes in the V. cholerae population, it would be possible to predict the direction of such changes and the evolution of new variants; this has implications for the battle against cholera." @default.
• W2110542485 created "2016-06-24" @default.
• W2110542485 creator A5026007401 @default.
• W2110542485 creator A5045566016 @default.
• W2110542485 creator A5062926395 @default.
• W2110542485 creator A5091466840 @default.
• W2110542485 date "2015-08-01" @default.
• W2110542485 modified "2023-10-16" @default.
• W2110542485 title "Whole-genome sequence comparisons reveal the evolution of Vibrio cholerae O1" @default.
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• W2110542485 doi "https://doi.org/10.1016/j.tim.2015.03.010" @default.
• W2110542485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25913612" @default.
• W2110542485 hasPublicationYear "2015" @default.
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