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• W2110543735 endingPage "583" @default.
• W2110543735 startingPage "577" @default.
• W2110543735 abstract "Helicobacter pylori-associated body gastritis inhibits gastric acid secretion. The aim of this study was to determine the effects of H. pylori infection on gastric acid secretion and further determine whether cyclooxygenase-2 was involved.C57BL/6 mice (n = 40) were inoculated with the Sydney strain of H. pylori. Control mice (n = 40) were treated with vehicle only. Half of the infected and control mice were fed an experimental diet containing etodolac (10 mg/kg/day) from 1 week after inoculation until the end of the experiment. Before, 12 and 24 weeks after inoculation, the gastric acid secretion, prostaglandin E2 (PGE2) levels in the gastric mucosa, and gastritis scores according to the updated Sydney system were determined. Immunohistochemical staining of COX-2 protein was also performed.No significant changes in gastric acid secretion, gastritis scores or PGE2 levels in the gastric mucosa were observed in uninfected groups with or without etodolac treatment during the study period. In the H. pylori-infected group without etodolac treatment, gastric acid secretion was significantly decreased with increases in PGE2 levels in the gastric mucosa 24 weeks after inoculation compared with the controls. Gastritis score for activity was significantly higher, and strong staining for COX-2 protein was observed in the H. pylori-infected group. In the H. pylori-infected group with etodolac treatment, PGE2 in the gastric mucosa was decreased and acid secretion was restored to the same level as in the control group.One of the mechanisms by which H. pylori infection inhibits gastric acid secretion is increased release of PGE2 produced by COX-2, which is induced by H. pylori infection." @default.
• W2110543735 created "2016-06-24" @default.
• W2110543735 creator A5016853432 @default.
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• W2110543735 date "2001-06-01" @default.
• W2110543735 modified "2023-10-14" @default.
• W2110543735 title "Effects of Cyclooxygenase-2 Inhibitor on Gastric Acid Secretion in Helicobacter pylori-infected C57BL/6 Mice" @default.
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• W2110543735 doi "https://doi.org/10.1080/003655201750162971" @default.
• W2110543735 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11424315" @default.
• W2110543735 hasPublicationYear "2001" @default.
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