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- W2110565561 abstract "Mast cells store and secrete a variety of pharmacologically active agents including heparin, histamine, immunoregulatory cytokines and the mast cell-specific serine proteases, tryptase and chymase. Although normally associated with very acute immunoglobulin E–dependent allergic reactions, mast cell activation has been shown to occur in conditions associated with tissue fibrosis, such as Crohn’s disease, scleroderma, and pulmonary fibrosis. Because mast cell enzymes have been implicated in the fibrotic response, we sought to examine the possible regulatory role of mast cells in bladder wall fibrosis. Hence, the objectives of this study were to determine if there was an increase in inflammatory mast cell number and location in bladder wall tissue from myelodysplasia patients, and to determine if the mast cell proteases, chymase and tryptase, could alter connective tissue expression in bladder wall cells." @default.
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- W2110565561 date "2001-06-01" @default.
- W2110565561 modified "2023-09-27" @default.
- W2110565561 title "Mast cell enzymes alter the connective tissue phenotype of bladder wall fibroblasts and smooth muscle cells" @default.
- W2110565561 doi "https://doi.org/10.1016/s0090-4295(01)01046-9" @default.
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