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- W2110572297 endingPage "861" @default.
- W2110572297 startingPage "848" @default.
- W2110572297 abstract "A central goal of evolutionary genetics is an understanding of the forces responsible for the observed variation, both within and between species. Theoretical and empirical work have demonstrated that genetic recombination contributes to this variation by breaking down linkage between nucleotide sites, thus allowing them to behave independently and for selective forces to act efficiently on them. The Drosophila fourth chromosome, which is believed to experience no-or very low-rates of recombination has been an important model for investigating these effects. Despite previous efforts, central questions regarding the extent of recombination and the predominant modes of selection acting on it remain open. In order to more comprehensively test hypotheses regarding recombination and its potential influence on selection along the fourth chromosome, we have resequenced regions from most of its genes from Drosophila melanogaster, D. simulans, and D. yakuba. These data, along with available outgroup sequence, demonstrate that recombination is low but significantly greater than zero for the three species. Despite there being recombination, there is strong evidence that its frequency is low enough to have rendered selection relatively inefficient. The signatures of relaxed constraint can be detected at both the level of polymorphism and divergence." @default.
- W2110572297 created "2016-06-24" @default.
- W2110572297 creator A5006381524 @default.
- W2110572297 creator A5009366844 @default.
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- W2110572297 creator A5049092086 @default.
- W2110572297 creator A5051518424 @default.
- W2110572297 creator A5084814231 @default.
- W2110572297 date "2009-12-14" @default.
- W2110572297 modified "2023-10-16" @default.
- W2110572297 title "Recombination Yet Inefficient Selection along the Drosophila melanogaster Subgroup's Fourth Chromosome" @default.
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- W2110572297 doi "https://doi.org/10.1093/molbev/msp291" @default.
- W2110572297 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2877538" @default.
- W2110572297 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20008457" @default.