FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110574705> ?p ?o ?g. }

• W2110574705 endingPage "10" @default.
• W2110574705 startingPage "1" @default.
• W2110574705 abstract "Background . The MC1R gene implicated in melanogenesis and skin pigmentation is highly polymorphic. Several alleles are associated with red hair and fair skin phenotypes and contribute to melanoma risk. Objective . This work aims to assess the effect of different classes of MC1R variants, notably rare variants, on melanoma risk. Methods . MC1R coding region was sequenced in 1131 melanoma patients and 869 healthy controls. MC1R variants were classified as RHC ( R ) and non-RHC ( r ). Rare variants (frequency < 1%) were subdivided into two subgroups, predicted to be damaging ( D ) or not ( nD ). Results . Both R and r alleles were associated with melanoma (OR = 2.66 [2.20–3.23] and 1.51 [1.32–1.73]) and had similar population attributable risks (15.8% and 16.6%). We also identified 69 rare variants, of which 25 were novel. D variants were strongly associated with melanoma (OR = 2.38 [1.38–4.15]) and clustered in the same MC1R domains as R alleles (intracellular 2, transmembrane 2 and 7). Conclusion . This work confirms the role of R and r alleles in melanoma risk in the French population and proposes a novel class of rare D variants as important melanoma risk factors. These findings may improve the definition of high-risk subjects that could be targeted for melanoma prevention and screening." @default.
• W2110574705 created "2016-06-24" @default.
• W2110574705 creator A5011037498 @default.
• W2110574705 creator A5013854073 @default.
• W2110574705 creator A5033499830 @default.
• W2110574705 creator A5034402801 @default.
• W2110574705 creator A5040446667 @default.
• W2110574705 creator A5042815092 @default.
• W2110574705 creator A5059444495 @default.
• W2110574705 creator A5066775464 @default.
• W2110574705 creator A5068469347 @default.
• W2110574705 creator A5069199796 @default.
• W2110574705 creator A5070386522 @default.
• W2110574705 creator A5074214434 @default.
• W2110574705 creator A5088876197 @default.
• W2110574705 creator A5089843536 @default.
• W2110574705 date "2014-01-01" @default.
• W2110574705 modified "2023-10-15" @default.
• W2110574705 title "A Large French Case-Control Study Emphasizes the Role of Rare<i>Mc1R</i>Variants in Melanoma Risk" @default.
• W2110574705 cites W1493014168 @default.
• W2110574705 cites W1498721833 @default.
• W2110574705 cites W1912033397 @default.
• W2110574705 cites W1963776674 @default.
• W2110574705 cites W1964719051 @default.
• W2110574705 cites W1979580952 @default.
• W2110574705 cites W1981605211 @default.
• W2110574705 cites W1989685898 @default.
• W2110574705 cites W1990857780 @default.
• W2110574705 cites W2001574640 @default.
• W2110574705 cites W2001670469 @default.
• W2110574705 cites W2007541023 @default.
• W2110574705 cites W2011925332 @default.
• W2110574705 cites W2014626078 @default.
• W2110574705 cites W2017090237 @default.
• W2110574705 cites W2024992394 @default.
• W2110574705 cites W2025654886 @default.
• W2110574705 cites W2027810940 @default.
• W2110574705 cites W2028130288 @default.
• W2110574705 cites W2034183785 @default.
• W2110574705 cites W2034710079 @default.
• W2110574705 cites W2035434596 @default.
• W2110574705 cites W2040984959 @default.
• W2110574705 cites W2040989827 @default.
• W2110574705 cites W2057117594 @default.
• W2110574705 cites W2057862077 @default.
• W2110574705 cites W2061734521 @default.
• W2110574705 cites W2062683044 @default.
• W2110574705 cites W2068336539 @default.
• W2110574705 cites W2069089202 @default.
• W2110574705 cites W2070332388 @default.
• W2110574705 cites W2072630073 @default.
• W2110574705 cites W2074065112 @default.
• W2110574705 cites W2074179023 @default.
• W2110574705 cites W2074283639 @default.
• W2110574705 cites W2081596026 @default.
• W2110574705 cites W2091298691 @default.
• W2110574705 cites W2094780514 @default.
• W2110574705 cites W2099911321 @default.
• W2110574705 cites W2105712032 @default.
• W2110574705 cites W2106675244 @default.
• W2110574705 cites W2116893702 @default.
• W2110574705 cites W2123300021 @default.
• W2110574705 cites W2123797367 @default.
• W2110574705 cites W2128725994 @default.
• W2110574705 cites W2140467818 @default.
• W2110574705 cites W2143260563 @default.
• W2110574705 cites W2146329232 @default.
• W2110574705 cites W2147450167 @default.
• W2110574705 cites W2158637523 @default.
• W2110574705 cites W4249098338 @default.
• W2110574705 doi "https://doi.org/10.1155/2014/925716" @default.
• W2110574705 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4003837" @default.
• W2110574705 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24982914" @default.
• W2110574705 hasPublicationYear "2014" @default.
• W2110574705 type Work @default.
• W2110574705 sameAs 2110574705 @default.
• W2110574705 citedByCount "16" @default.
• W2110574705 countsByYear W21105747052015 @default.
• W2110574705 countsByYear W21105747052016 @default.
• W2110574705 countsByYear W21105747052017 @default.
• W2110574705 countsByYear W21105747052018 @default.
• W2110574705 countsByYear W21105747052019 @default.
• W2110574705 countsByYear W21105747052020 @default.
• W2110574705 countsByYear W21105747052021 @default.
• W2110574705 countsByYear W21105747052022 @default.
• W2110574705 crossrefType "journal-article" @default.
• W2110574705 hasAuthorship W2110574705A5011037498 @default.
• W2110574705 hasAuthorship W2110574705A5013854073 @default.
• W2110574705 hasAuthorship W2110574705A5033499830 @default.
• W2110574705 hasAuthorship W2110574705A5034402801 @default.
• W2110574705 hasAuthorship W2110574705A5040446667 @default.
• W2110574705 hasAuthorship W2110574705A5042815092 @default.
• W2110574705 hasAuthorship W2110574705A5059444495 @default.
• W2110574705 hasAuthorship W2110574705A5066775464 @default.
• W2110574705 hasAuthorship W2110574705A5068469347 @default.
• W2110574705 hasAuthorship W2110574705A5069199796 @default.
• W2110574705 hasAuthorship W2110574705A5070386522 @default.
• W2110574705 hasAuthorship W2110574705A5074214434 @default.

• next