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• W2110583844 abstract "The C. elegans HIF-1 proline hydroxylase EGL-9 functions as an O(2) sensor in an evolutionarily conserved pathway for adaptation to hypoxia. H(2)S accumulates during hypoxia and promotes HIF-1 activity, but how H(2)S signals are perceived and transmitted to modulate HIF-1 and animal behavior is unknown. We report that the experience of hypoxia modifies a C. elegans locomotive behavioral response to O(2) through the EGL-9 pathway. From genetic screens to identify novel regulators of EGL-9-mediated behavioral plasticity, we isolated mutations of the gene cysl-1, which encodes a C. elegans homolog of sulfhydrylases/cysteine synthases. Hypoxia-dependent behavioral modulation and H(2)S-induced HIF-1 activation require the direct physical interaction of CYSL-1 with the EGL-9 C terminus. Sequestration of EGL-9 by CYSL-1 and inhibition of EGL-9-mediated hydroxylation by hypoxia together promote neuronal HIF-1 activation to modulate behavior. These findings demonstrate that CYSL-1 acts to transduce signals from H(2)S to EGL-9 to regulate O(2)-dependent behavioral plasticity in C. elegans." @default.
• W2110583844 created "2016-06-24" @default.
• W2110583844 creator A5020931583 @default.
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• W2110583844 date "2012-03-01" @default.
• W2110583844 modified "2023-10-14" @default.
• W2110583844 title "CYSL-1 Interacts with the O2-Sensing Hydroxylase EGL-9 to Promote H2S-Modulated Hypoxia-Induced Behavioral Plasticity in C. elegans" @default.
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• W2110583844 doi "https://doi.org/10.1016/j.neuron.2011.12.037" @default.
• W2110583844 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3305813" @default.
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• W2110583844 hasPublicationYear "2012" @default.
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