FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110586413> ?p ?o ?g. }

• W2110586413 endingPage "547" @default.
• W2110586413 startingPage "537" @default.
• W2110586413 abstract "Abstract The components of receptor tyrosine kinase signaling complexes help to define the specificity of the effects of their activation. The Caenorhabditis elegans fibroblast growth factor receptor (FGFR), EGL-15, regulates a number of processes, including sex myoblast (SM) migration guidance and fluid homeostasis, both of which require a Grb2/Sos/Ras cassette of signaling components. Here we show that SEM-5/Grb2 can bind directly to EGL-15 to mediate SM chemoattraction. A yeast two-hybrid screen identified SEM-5 as able to interact with the carboxy-terminal domain (CTD) of EGL-15, a domain that is specifically required for SM chemoattraction. This interaction requires the SEM-5 SH2-binding motifs present in the CTD (Y1009 and Y1087), and these sites are required for the CTD role of EGL-15 in SM chemoattraction. SEM-5, but not the SEM-5 binding sites located in the CTD, is required for the fluid homeostasis function of EGL-15, indicating that SEM-5 can link to EGL-15 through an alternative mechanism. The multi-substrate adaptor protein FRS2 serves to link vertebrate FGFRs to Grb2. In C. elegans, an FRS2-like gene, rog-1, functions upstream of a Ras/MAPK pathway for oocyte maturation but is not required for EGL-15 function. Thus, unlike the vertebrate FGFRs, which require the multi-substrate adaptor FRS2 to recruit Grb2, EGL-15 can recruit SEM-5/Grb2 directly." @default.
• W2110586413 created "2016-06-24" @default.
• W2110586413 creator A5005427405 @default.
• W2110586413 creator A5034476604 @default.
• W2110586413 creator A5042356923 @default.
• W2110586413 creator A5064165286 @default.
• W2110586413 date "2010-06-01" @default.
• W2110586413 modified "2023-10-15" @default.
• W2110586413 title "<i>Caenorhabditis elegans</i> Fibroblast Growth Factor Receptor Signaling Can Occur Independently of the Multi-Substrate Adaptor FRS2" @default.
• W2110586413 cites W1647075334 @default.
• W2110586413 cites W1944127002 @default.
• W2110586413 cites W1967747965 @default.
• W2110586413 cites W1986006829 @default.
• W2110586413 cites W1989983474 @default.
• W2110586413 cites W1996782310 @default.
• W2110586413 cites W2003870815 @default.
• W2110586413 cites W2008493684 @default.
• W2110586413 cites W2013592169 @default.
• W2110586413 cites W2019597856 @default.
• W2110586413 cites W2021862373 @default.
• W2110586413 cites W2025870139 @default.
• W2110586413 cites W2028634080 @default.
• W2110586413 cites W2030408404 @default.
• W2110586413 cites W2033073864 @default.
• W2110586413 cites W2041386911 @default.
• W2110586413 cites W2044374752 @default.
• W2110586413 cites W2045860277 @default.
• W2110586413 cites W2046407078 @default.
• W2110586413 cites W2047654571 @default.
• W2110586413 cites W2050126593 @default.
• W2110586413 cites W2051628416 @default.
• W2110586413 cites W2055519466 @default.
• W2110586413 cites W2056983875 @default.
• W2110586413 cites W2058202542 @default.
• W2110586413 cites W2061734201 @default.
• W2110586413 cites W2062221068 @default.
• W2110586413 cites W2064953500 @default.
• W2110586413 cites W2065483613 @default.
• W2110586413 cites W2074038463 @default.
• W2110586413 cites W2079910146 @default.
• W2110586413 cites W2083048322 @default.
• W2110586413 cites W2086334047 @default.
• W2110586413 cites W2095127655 @default.
• W2110586413 cites W2097125189 @default.
• W2110586413 cites W2097557938 @default.
• W2110586413 cites W2100281377 @default.
• W2110586413 cites W2110422486 @default.
• W2110586413 cites W2112688349 @default.
• W2110586413 cites W2124649128 @default.
• W2110586413 cites W2144005841 @default.
• W2110586413 cites W2148973479 @default.
• W2110586413 cites W2156981424 @default.
• W2110586413 cites W2164331820 @default.
• W2110586413 cites W2164682544 @default.
• W2110586413 cites W2165080661 @default.
• W2110586413 cites W2166384423 @default.
• W2110586413 cites W2167822739 @default.
• W2110586413 cites W2183003006 @default.
• W2110586413 cites W2187192485 @default.
• W2110586413 cites W2187989464 @default.
• W2110586413 cites W2330422186 @default.
• W2110586413 doi "https://doi.org/10.1534/genetics.109.113373" @default.
• W2110586413 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2881135" @default.
• W2110586413 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20308281" @default.
• W2110586413 hasPublicationYear "2010" @default.
• W2110586413 type Work @default.
• W2110586413 sameAs 2110586413 @default.
• W2110586413 citedByCount "11" @default.
• W2110586413 countsByYear W21105864132013 @default.
• W2110586413 countsByYear W21105864132016 @default.
• W2110586413 countsByYear W21105864132018 @default.
• W2110586413 countsByYear W21105864132020 @default.
• W2110586413 countsByYear W21105864132021 @default.
• W2110586413 countsByYear W21105864132022 @default.
• W2110586413 countsByYear W21105864132023 @default.
• W2110586413 crossrefType "journal-article" @default.
• W2110586413 hasAuthorship W2110586413A5005427405 @default.
• W2110586413 hasAuthorship W2110586413A5034476604 @default.
• W2110586413 hasAuthorship W2110586413A5042356923 @default.
• W2110586413 hasAuthorship W2110586413A5064165286 @default.
• W2110586413 hasBestOaLocation W21105864131 @default.
• W2110586413 hasConcept C101544691 @default.
• W2110586413 hasConcept C104317684 @default.
• W2110586413 hasConcept C170493617 @default.
• W2110586413 hasConcept C177917778 @default.
• W2110586413 hasConcept C183786373 @default.
• W2110586413 hasConcept C2778944004 @default.
• W2110586413 hasConcept C54355233 @default.
• W2110586413 hasConcept C62478195 @default.
• W2110586413 hasConcept C74373430 @default.
• W2110586413 hasConcept C82867764 @default.
• W2110586413 hasConcept C86803240 @default.
• W2110586413 hasConcept C95444343 @default.
• W2110586413 hasConceptScore W2110586413C101544691 @default.
• W2110586413 hasConceptScore W2110586413C104317684 @default.
• W2110586413 hasConceptScore W2110586413C170493617 @default.
• W2110586413 hasConceptScore W2110586413C177917778 @default.
• W2110586413 hasConceptScore W2110586413C183786373 @default.

• next