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• W2110588162 abstract "Substance P (SP) is a neuropeptide well known for its contribution to pain transmission in the spinal cord, however, less is known about the possible modulatory effects of SP. A new study by Gu and colleagues, published in Molecular Pain (2005, 1:20), describes its potential role in feed-forward inhibition in lamina V of the dorsal horn of the spinal cord. This inhibition seems to function through a direct excitation of GABAergic interneurons by substance P released from primary afferent fibers and has a distinct temporal phase of action from the well-described glutamate-dependent feed-forward inhibition. It is believed that through this inhibition, substance P can balance nociceptive output from the spinal cord." @default.
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• W2110588162 date "2005-01-01" @default.
• W2110588162 modified "2023-09-25" @default.
• W2110588162 title "Feed-Forward Inhibition: A Novel Cellular Mechanism for the Analgesic Effect of Substance P" @default.
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• W2110588162 doi "https://doi.org/10.1186/1744-8069-1-34" @default.
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