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• W2110588649 abstract "Amyloid fibril formation is a nucleation dependent process characterized by a lag-phase prior to the appearance of detectable amyloid fibrils. While the three-dimensional structure of amyloid fibrils at atomic resolution is just beginning to be elucidated, the early process of monomers assembly into oligomers is less understood. Understanding the dynamic processes that lead to the formation of these intermediates is highly important as these assemblies might be the most pathological ones. Here, we investigated the biophysical and structural features characterizing the early stage assemblies formed by the human hormone calcitonin. We calculated the initial nucleus size by experimentally determining the dependence between the lag-time length and the hCT concentrations. We used size exclusion chromatography and dynamic light scattering in order to characterize the dynamic growth process of preliminary intermediates transformed into larger structures. The early structures were visualized using high-resolution transmission electron microscopy. Annular pore-like structures were observed along with protofibrilar structures. This observed morphology is similar to structures revealed during the fibrillization processes of β-amyloid, α-synuclein, and islet amyloid polypeptide, suggesting that these intermediates represent a generic early structure conformation. The results introduced here imply that a variety of intermediate assemblies are formed during the early stages of amyloid fibril formation. The characterizing of their structural features and assembly kinetics will contribute to the rational design of inhibitors directed towards early structure assemblies." @default.
• W2110588649 created "2016-06-24" @default.
• W2110588649 creator A5066386028 @default.
• W2110588649 creator A5082716768 @default.
• W2110588649 date "2006-01-01" @default.
• W2110588649 modified "2023-10-10" @default.
• W2110588649 title "The early stages of amyloid formation: Biophysical and structural characterization of human calcitonin pre-fibrillar assemblies" @default.
• W2110588649 cites W1532542691 @default.
• W2110588649 cites W1587588813 @default.
• W2110588649 cites W1638673169 @default.
• W2110588649 cites W1745469069 @default.
• W2110588649 cites W1972240368 @default.
• W2110588649 cites W1973130935 @default.
• W2110588649 cites W1976679680 @default.
• W2110588649 cites W1980450721 @default.
• W2110588649 cites W1986625112 @default.
• W2110588649 cites W1992841048 @default.
• W2110588649 cites W2000147308 @default.
• W2110588649 cites W2001407922 @default.
• W2110588649 cites W2004427274 @default.
• W2110588649 cites W2007542494 @default.
• W2110588649 cites W2012561243 @default.
• W2110588649 cites W2015245568 @default.
• W2110588649 cites W2020069228 @default.
• W2110588649 cites W2020796799 @default.
• W2110588649 cites W2023531011 @default.
• W2110588649 cites W2027398076 @default.
• W2110588649 cites W2029695041 @default.
• W2110588649 cites W2031489128 @default.
• W2110588649 cites W2032136893 @default.
• W2110588649 cites W2038197478 @default.
• W2110588649 cites W2039376206 @default.
• W2110588649 cites W2041537319 @default.
• W2110588649 cites W2042726738 @default.
• W2110588649 cites W2044862505 @default.
• W2110588649 cites W2046974636 @default.
• W2110588649 cites W2051651977 @default.
• W2110588649 cites W2052647401 @default.
• W2110588649 cites W2054850880 @default.
• W2110588649 cites W2056776699 @default.
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• W2110588649 cites W2080541432 @default.
• W2110588649 cites W2092625134 @default.
• W2110588649 cites W2096180119 @default.
• W2110588649 cites W2096601751 @default.
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• W2110588649 doi "https://doi.org/10.1080/13506120600960643" @default.
• W2110588649 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17107882" @default.
• W2110588649 hasPublicationYear "2006" @default.
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