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• W2110589504 abstract "This study examined the capability of Candida albicans and Cryptococcus neoformans to modulate CD4 expression on human monocytes. C. albicans and an acapsular strain of C. neoformans induced higher levels of CD4 expression than encapsulated strains. Purified glucuronoxylomannan did not regulate CD4 expression on monocytes, but down-regulation of CD4 expression compared with stimulation by acapsular C. neoformans alone was observed when glucuronoxylomannan was used in combination with acapsular C. neoformans. The ability of opsonic factors to facilitate fungal-mediated CD4 overexpression suggests that binding or internalization (or both) of the yeast cells is a critical event. Protein synthesis was required, excluding redistribution of the intracellular pool of CD4 receptors to the cellular surface as the sole possible mechanism. Results demonstrate a new effect of fungi on professional phagocytic cells and raise the possibility that modulation of CD4 could influence gp120-mediated human immunodeficiency virus entry." @default.
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• W2110589504 date "1998-11-01" @default.
• W2110589504 modified "2023-10-18" @default.
• W2110589504 title "<i>Cryptococcus neoformans</i>and<i>Candida albicans</i>Regulate CD4 Expression on Human Monocytes" @default.
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• W2110589504 doi "https://doi.org/10.1086/314458" @default.
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