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• W2110592001 abstract "<h3>Objectives</h3> To assess the role of serum amylase and lipase in the diagnosis of acute pancreatitis. Secondary aims were to perform a cost analysis of these enzyme assays in patients admitted to the surgical admissions unit. <h3>Design</h3> Cohort study. <h3>Setting</h3> Secondary care. <h3>Participants</h3> Patients admitted with pancreatitis to the acute surgical admissions unit from January to December 2010 were included in the study. <h3>Methods</h3> Data collated included demographics, laboratory results and aetiology. The cost of measuring a single enzyme assay was £0.69 and both assays were £0.99. <h3>Results</h3> Of the 151 patients included, 117 patients had acute pancreatitis with gallstones (n=51) as the most common cause. The majority of patients with acute pancreatitis had raised levels of both amylase and lipase. Raised lipase levels only were observed in additional 12% and 23% of patients with gallstone-induced and alcohol-induced pancreatitis, respectively. Overall, raised lipase levels were seen in between 95% and 100% of patients depending on aetiology. Sensitivity and specificity of lipase in the diagnosis of acute pancreatitis was 96.6% and 99.4%, respectively. In contrast, the sensitivity and specificity of amylase in diagnosing acute pancreatitis were 78.6% and 99.1%, respectively. Single lipase assay in all patients presenting with abdominal pain to the surgical admission unit would result in a potential saving of £893.70/year. <h3>Conclusions</h3> Determining serum lipase level alone is sufficient to diagnose acute pancreatitis and substantial savings can be made if measured alone." @default.
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• W2110592001 date "2012-01-01" @default.
• W2110592001 modified "2023-10-16" @default.
• W2110592001 title "Retrospective study of patients with acute pancreatitis: is serum amylase still required?" @default.
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• W2110592001 doi "https://doi.org/10.1136/bmjopen-2012-001471" @default.
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