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- W2110595633 abstract "Deoxynivalenol (DON) is a mycotoxin contaminant of cereal crops, and whilst animal toxicity has demonstrated its role at low doses in animals, and in human toxicity in general remains unclear. Here we investigated potential biological markers in sera using samples obtained from a previous DON-controlled feeding study on weanling piglets. Piglets (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>10</mml:mn></mml:mrow></mml:math> per group) received diets containing 0 (control), 240, 560-or 840 μ g DON/kg feed for 28 days. Plasma samples collected at the end of the DON exposure trial were reassessed, using nuclear magnetic resonance (NMR). A modest trend was observed between plasma glucose concentration and DON ingestion (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mrow><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.04</mml:mn></mml:mrow></mml:math>). Plasma DON (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mrow><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.04</mml:mn></mml:mrow></mml:math>) and plasma protein-associated DON (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mrow><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.08</mml:mn></mml:mrow></mml:math>) were moderately correlated with DON ingestion in a more limited survey of a subset of samples used for glucose analysis (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mrow><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>20</mml:mn></mml:mrow></mml:math>). This is a preliminary study but suggests that a more detailed survey of the temporal nature of these biological measures is warranted." @default.
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- W2110595633 date "2012-11-14" @default.
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- W2110595633 title "Nuclear Magnetic Resonance Analysis of Glucose Levels in Weanling Piglets Plasma as a Function of Deoxynivalenol Exposure" @default.
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- W2110595633 doi "https://doi.org/10.5402/2012/132543" @default.
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