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- W2110604145 abstract "ABSTRACT The case of a patient with visceral leishmaniasis showing inadequate response to amphotericin B from a region where leishmaniasis is not endemic is reported, with the Leishmania donovani isolate showing increased tolerance to amphotericin B in vivo . Four single nucleotide polymorphisms (SNPs) detected in the cysteine proteinase B gene resulted in changes to the deduced amino acid sequence: valine→alanine and arginine→leucine. Overexpression and underexpression of proteins were observed in the 65- to 80-kDa range and at 20 kDa, respectively." @default.
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- W2110604145 date "2011-08-01" @default.
- W2110604145 modified "2023-10-16" @default.
- W2110604145 title "Unusual Case of Resistance to Amphotericin B in Visceral Leishmaniasis in a Region in India Where Leishmaniasis Is Not Endemic" @default.
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- W2110604145 doi "https://doi.org/10.1128/jcm.00173-11" @default.
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