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• W2110608506 abstract "To look for cerebral white matter MRI changes in patients with long-standing and disabling MS.We analyzed retrospectively brain MRIs (performed 10 or more years after symptom onset) of patients with MS diagnosis and expanded disability status scale of 6 or more. The following parameters were analyzed: total number of brain T2 hyperintensities; number of brainstem, cerebellar, corpus callosum, basal ganglia, and juxtacortical T2 hyperintensities; diffuse leukoencephalopathy score; total number of T1 hypointensities.Eighty-four patients were included. The mean time between symptom onset and MRI was 20.2 years. Eight percent had less than 9 cerebral T2 hyperintensities. Posterior fossa, juxtacortical, and corpus callosum T2 hyperintensities, and T1 hypointensities lacked in respectively 19%, 12%, 47%, and 8%. Overall, normal MRI was not seen, 6% had abnormal MRI but did not meet Barkhof's criteria, and the remaining 94% had MRI abnormalities fulfilling Barkhof's criteria. Moderate or severe diffuse leukoencephalopathy was seen in 69%. Extensive diffuse leukoencephalopathy predominant to nodular lesions was seen in 5%.Despite long-standing and disabling MS, typical MRI abnormalities lacked in a minority of patients, and 6% did not fulfil Barkhof's criteria. The majority showed moderate or severe diffuse leukoencephalopathy." @default.
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• W2110608506 date "2010-05-01" @default.
• W2110608506 modified "2023-09-30" @default.
• W2110608506 title "Brain MRI findings in long-standing and disabling multiple sclerosis in 84 patients" @default.
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• W2110608506 doi "https://doi.org/10.1016/j.clineuro.2009.12.012" @default.
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