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- W2110611907 abstract "Studies performed over the last 10 years have clearly shown that glucagon plays a pivotal role in the normal control of blood glucose as well as being extremely important in the pathogenesis of the metabolic abnormalities found in a number of disease states (Jaspan and Rubenstein 1977). Thus, glucagon is important for the maintenance of normal blood glucose levels in the fasted state (Marliss et al. 1970; Alford et al. 1974) as well as after protein feeding (Unger et al. 1969) and during exercise (Issekutz and Vranic 1980). Glucagon is the most important defense against the development of hypoglycemia induced by insulin (Rizza et al. 1979). Although its precise role in the pathogenesis of diabetes is uncertain, there is substantial evidence that glucagon is important in aggravating the hyperglycemia due to insulin deficiency (Unger 1976; Unger and Orci 1981; Gerich 1976) as well as being essential for the development of ketoacidosis in the insulin-deprived state (Mcgarry and Foster 1977; Gerich et al. 1974). Elevated levels of glucagon are found in cirrhosis (Marco et al. 1973; Sherwin et al. 1974), renal failure (Kuku et al. 1976), glucagonoma (Jaspan and Rubenstein 1977), and stress conditions such as shock (Unger 1971; Willerson et al. 1974), and the hyperglucagonemia probably contributes to the glucose intolerance found in all of these conditions." @default.
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- W2110611907 date "1983-01-01" @default.
- W2110611907 modified "2023-10-15" @default.
- W2110611907 title "The Metabolic Clearance Rate of Glucagon" @default.
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- W2110611907 doi "https://doi.org/10.1007/978-3-642-69019-8_17" @default.
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