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- W2110613868 abstract "Pulmonary Arterial Hypertension (PAH) is a devastating disease that, until recently, had no effective medical therapy. In 1996, a prostacyclin, epoprostenol, was approved; since then, several therapies, including prostacyclin analogues and agents that modulate other vasoactive pathways – endothelin receptor antagonists and phosphodiesterase inhibitors – have received approval. In this issue of Circulation , Galie et al report the results of the 2 pivotal trials of the endothelin receptor antagonist, ambrisentan, that lead the US Food and Drug Administration to approve this agent in June 2007.1Article p 3010 With the approval of ambrisentan, 6 different pulmonary-specific vasodilators delivered by various routes have now been approved in the United States for treatment of PAH; moreover, numerous other therapies have either been submitted for approval or are in development. Most physicians who treat PAH are aware of the data that lead to approval of ambrisentan; for this reason, it would seem more logically an opportune time to examine critically the current status of treatment for PAH.With that in mind; I will focus on several issues: (1) Where are we in the treatment of PAH? (2) Are we happy with where we are? (3) If not, why not? and (4) What do we need to do to get there?Although we “pulmonary hypertensionologists” think we have made a significant impact on this disease, is this really true? We believe that we have improved the clinical status of our patients and their survival, but do we have data to support our “gestalt” or has the recognition of the disease and its background treatment changed to such a degree that the pulmonary-specific medications have not really had much of an impact? A recent meta-analysis of randomized clinical trials in PAH suggests that we may have overestimated our success.2This meta-analysis reviewed …" @default.
- W2110613868 created "2016-06-24" @default.
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- W2110613868 date "2008-06-10" @default.
- W2110613868 modified "2023-09-27" @default.
- W2110613868 title "The Status of Pulmonary Arterial Hypertension in 2008" @default.
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- W2110613868 doi "https://doi.org/10.1161/circulationaha.108.782979" @default.
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