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- W2110618106 endingPage "2205" @default.
- W2110618106 startingPage "2195" @default.
- W2110618106 abstract "Mammalian sex determination hinges on the development of ovaries or testes, with testis fate being triggered by the expression of the transcription factor sex-determining region Y (Sry). Reduced or delayed Sry expression impairs testis development, highlighting the importance of its accurate spatiotemporal regulation and implying a potential role for SRY dysregulation in human intersex disorders. Several epigenetic modifiers, transcription factors and kinases are implicated in regulating Sry transcription, but it remains unclear whether or how this farrago of factors acts co-ordinately. Here we review our current understanding of Sry regulation and provide a model that assembles all known regulators into three modules, each converging on a single transcription factor that binds to the Sry promoter. We also discuss potential future avenues for discovering the cis-elements and trans-factors required for Sry regulation." @default.
- W2110618106 created "2016-06-24" @default.
- W2110618106 creator A5017222669 @default.
- W2110618106 creator A5039506361 @default.
- W2110618106 creator A5050712364 @default.
- W2110618106 date "2014-06-01" @default.
- W2110618106 modified "2023-10-15" @default.
- W2110618106 title "Switching on sex: transcriptional regulation of the testis-determining gene <i>Sry</i>" @default.
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