FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110626075> ?p ?o ?g. }

• W2110626075 endingPage "884" @default.
• W2110626075 startingPage "884" @default.
• W2110626075 abstract "Freezing of gait (FOG) is a common axial symptom of Parkinson disease (PD).To determine the prevalence of FOG in a large group of PD patients, assess its relationship with quality of life and clinical and pharmacological factors, and explore its changes from the off to on conditions in patients with motor fluctuations.Cross-sectional survey of 683 patients with idiopathic PD. Scores for FOG were missing in 11 patients who were not included in the analysis. Patients were recruited from referral centers and general neurology clinics in public or private institutions in France.Patients with FOG were identified as those with a score of 1 or greater on item 14 of the Unified Parkinson's Disease Rating Scale (UPDRS) in the on condition. Item 14 scores for FOG in the off condition were also collected in patients with fluctuating motor symptoms.Quality of life (measured by the 39-item Parkinson's Disease Questionnaire and 36-Item Short Form Health Survey), anxiety and depression (Hospital Anxiety and Depression Scale), clinical features (UPDRS), and drug consumption.Of 672 PD patients, 257 reported FOG during the onstate (38.2%), which was significantly related to lower quality of life scores (P < .01). Freezing of gait was also correlated with longer PD duration (odds ratio, 1.92 [95% CI, 1.28-2.86]), higher UPDRS parts II and III scores (4.67 [3.21-6.78]), the presence of apathy (UPDRS item 4) (1.94 [1.33-2.82]), a higher levodopa equivalent daily dose (1.63 [1.09-2.43]), and more frequent exposure to antimuscarinics (3.07 [1.35-6.97]) (logistic regression). The FOG score improved from the off to on states in 148 of 174 patients with motor fluctuations (85.1%) and showed no change in 13.8%. The FOG score improved by more than 50% in 43.7% of patients. Greater improvement in the on state was observed in younger patients (r = -0.25; P < .01) with lower UPDRS II and III scores (r = -0.50; P < .01) and no antimuscarinic use (r = -0.21; P < .01).Freezing of gait in PD patients correlates with poor quality of life, disease severity, apathy, and exposure to antimuscarinics. Dopaminergic therapy improved FOG in most patients with motor fluctuations, especially younger ones with less severe disease and no antimuscarinic use. This finding suggests that quality of life is impaired in PD patients with FOG and that optimizing dopaminergic therapy and avoiding antimuscarinics should be considered." @default.
• W2110626075 created "2016-06-24" @default.
• W2110626075 creator A5013406022 @default.
• W2110626075 creator A5032295591 @default.
• W2110626075 creator A5035913487 @default.
• W2110626075 creator A5040964710 @default.
• W2110626075 creator A5050945427 @default.
• W2110626075 creator A5054027214 @default.
• W2110626075 creator A5063519251 @default.
• W2110626075 creator A5082957589 @default.
• W2110626075 creator A5084614058 @default.
• W2110626075 creator A5089727621 @default.
• W2110626075 date "2014-07-01" @default.
• W2110626075 modified "2023-10-18" @default.
• W2110626075 title "Prevalence, Determinants, and Effect on Quality of Life of Freezing of Gait in Parkinson Disease" @default.
• W2110626075 cites W1562359367 @default.
• W2110626075 cites W1591055026 @default.
• W2110626075 cites W1847168837 @default.
• W2110626075 cites W1968018273 @default.
• W2110626075 cites W1975313451 @default.
• W2110626075 cites W1978103789 @default.
• W2110626075 cites W1991956550 @default.
• W2110626075 cites W2003673553 @default.
• W2110626075 cites W2008560062 @default.
• W2110626075 cites W2008669111 @default.
• W2110626075 cites W201588874 @default.
• W2110626075 cites W2017277727 @default.
• W2110626075 cites W2025926226 @default.
• W2110626075 cites W2030038103 @default.
• W2110626075 cites W2031041233 @default.
• W2110626075 cites W2037377025 @default.
• W2110626075 cites W2042094283 @default.
• W2110626075 cites W2054367000 @default.
• W2110626075 cites W2062666762 @default.
• W2110626075 cites W2063024868 @default.
• W2110626075 cites W2064996887 @default.
• W2110626075 cites W2072878089 @default.
• W2110626075 cites W2078649252 @default.
• W2110626075 cites W2084404118 @default.
• W2110626075 cites W2089085990 @default.
• W2110626075 cites W2089237335 @default.
• W2110626075 cites W2093940619 @default.
• W2110626075 cites W2100039954 @default.
• W2110626075 cites W2126630599 @default.
• W2110626075 cites W2132894148 @default.
• W2110626075 cites W2135072527 @default.
• W2110626075 cites W2138454607 @default.
• W2110626075 cites W2140978740 @default.
• W2110626075 cites W2149769408 @default.
• W2110626075 cites W2159003861 @default.
• W2110626075 cites W2159552567 @default.
• W2110626075 cites W2166281097 @default.
• W2110626075 cites W2171478009 @default.
• W2110626075 cites W29071921 @default.
• W2110626075 cites W3023211482 @default.
• W2110626075 doi "https://doi.org/10.1001/jamaneurol.2014.753" @default.
• W2110626075 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24839938" @default.
• W2110626075 hasPublicationYear "2014" @default.
• W2110626075 type Work @default.
• W2110626075 sameAs 2110626075 @default.
• W2110626075 citedByCount "226" @default.
• W2110626075 countsByYear W21106260752014 @default.
• W2110626075 countsByYear W21106260752015 @default.
• W2110626075 countsByYear W21106260752016 @default.
• W2110626075 countsByYear W21106260752017 @default.
• W2110626075 countsByYear W21106260752018 @default.
• W2110626075 countsByYear W21106260752019 @default.
• W2110626075 countsByYear W21106260752020 @default.
• W2110626075 countsByYear W21106260752021 @default.
• W2110626075 countsByYear W21106260752022 @default.
• W2110626075 countsByYear W21106260752023 @default.
• W2110626075 crossrefType "journal-article" @default.
• W2110626075 hasAuthorship W2110626075A5013406022 @default.
• W2110626075 hasAuthorship W2110626075A5032295591 @default.
• W2110626075 hasAuthorship W2110626075A5035913487 @default.
• W2110626075 hasAuthorship W2110626075A5040964710 @default.
• W2110626075 hasAuthorship W2110626075A5050945427 @default.
• W2110626075 hasAuthorship W2110626075A5054027214 @default.
• W2110626075 hasAuthorship W2110626075A5063519251 @default.
• W2110626075 hasAuthorship W2110626075A5082957589 @default.
• W2110626075 hasAuthorship W2110626075A5084614058 @default.
• W2110626075 hasAuthorship W2110626075A5089727621 @default.
• W2110626075 hasBestOaLocation W21106260751 @default.
• W2110626075 hasConcept C118552586 @default.
• W2110626075 hasConcept C126322002 @default.
• W2110626075 hasConcept C138496976 @default.
• W2110626075 hasConcept C139719470 @default.
• W2110626075 hasConcept C151800584 @default.
• W2110626075 hasConcept C156957248 @default.
• W2110626075 hasConcept C15744967 @default.
• W2110626075 hasConcept C159110408 @default.
• W2110626075 hasConcept C162324750 @default.
• W2110626075 hasConcept C16568411 @default.
• W2110626075 hasConcept C1862650 @default.
• W2110626075 hasConcept C2776509080 @default.
• W2110626075 hasConcept C2776867660 @default.
• W2110626075 hasConcept C2779134260 @default.
• W2110626075 hasConcept C2779734285 @default.

• next