Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110647791> ?p ?o ?g. }
- W2110647791 endingPage "669" @default.
- W2110647791 startingPage "655" @default.
- W2110647791 abstract "Severe SARS-CoV-2 infection often leads to the development of acute respiratory distress syndrome (ARDS), with profound pulmonary patho-histological changes post-mortem. It is not clear whether ARDS from SARS-CoV-2 is similar to that observed in influenza H1N1, another common viral cause of lung injury. Here, we analyze specific ARDS regions of interest utilizing a spatial transcriptomic platform on autopsy-derived lung tissue from patients with SARS-CoV-2 (n = 3), H1N1 (n = 3), and a dual infected individual (n = 1). Enhanced gene signatures in alveolar epithelium, vascular tissue, and lung macrophages identify not only increased regional coagulopathy but also increased extracellular remodeling, alternative macrophage activation, and squamous metaplasia of type II pneumocytes in SARS-CoV-2. Both the H1N1 and dual-infected transcriptome demonstrated an enhanced antiviral response compared to SARS-CoV-2. Our results uncover regional transcriptional changes related to tissue damage/remodeling, altered cellular phenotype, and vascular injury active in SARS-CoV-2 and present therapeutic targets for COVID-19-related ARDS." @default.
- W2110647791 created "2016-06-24" @default.
- W2110647791 creator A5020820588 @default.
- W2110647791 creator A5084997419 @default.
- W2110647791 date "2006-12-01" @default.
- W2110647791 modified "2023-09-26" @default.
- W2110647791 title "The Alveolar–Epithelial Barrier: A Target for Potential Therapy" @default.
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