FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110648151> ?p ?o ?g. }

• W2110648151 endingPage "e22744" @default.
• W2110648151 startingPage "e22744" @default.
• W2110648151 abstract "Early-onset torsion dystonia is a severe, life-long disease that leads to loss of motor control and involuntary muscle contractions. While the molecular etiology of the disease is not fully understood, a mutation in an AAA+ ATPase, torsinA, has been linked to disease onset. Previous work on torsinA has shown that it localizes to the endoplasmic reticulum, where there is evidence that it plays roles in protein trafficking, and potentially also protein folding. Given the high level of evolutionary conservation among proteins involved in these processes, the ability of human such proteins to function effectively in yeast, as well as the previous successes achieved in examining other proteins involved in complex human diseases in yeast, we hypothesized that Saccharomyces cerevisiae might represent a useful model system for studying torsinA function and the effects of its mutants. Since torsinA is proposed to function in protein homeostasis, we tested cells for their ability to respond to various stressors, using a fluorescent reporter to measure the unfolded protein response, as well as their rate of protein secretion. TorsinA did not impact these processes, even after co-expression of its recently identified interacting partner, printor. In light of these findings, we propose that yeast may lack an additional cofactor necessary for torsinA function or proteins required for essential post-translational modifications of torsinA. Alternatively, torsinA may not function in endoplasmic reticulum protein homeostasis. The strains and assays we describe may provide useful tools for identifying and investigating these possibilities and are freely available." @default.
• W2110648151 created "2016-06-24" @default.
• W2110648151 creator A5019700045 @default.
• W2110648151 creator A5070753307 @default.
• W2110648151 date "2011-07-26" @default.
• W2110648151 modified "2023-09-26" @default.
• W2110648151 title "TorsinA and the TorsinA-Interacting Protein Printor Have No Impact on Endoplasmic Reticulum Stress or Protein Trafficking in Yeast" @default.
• W2110648151 cites W1505736052 @default.
• W2110648151 cites W1506853129 @default.
• W2110648151 cites W1507128123 @default.
• W2110648151 cites W1535037813 @default.
• W2110648151 cites W1563231805 @default.
• W2110648151 cites W1971497139 @default.
• W2110648151 cites W1980431043 @default.
• W2110648151 cites W1985183002 @default.
• W2110648151 cites W1986508375 @default.
• W2110648151 cites W1986720797 @default.
• W2110648151 cites W1987820478 @default.
• W2110648151 cites W1988259487 @default.
• W2110648151 cites W1990400035 @default.
• W2110648151 cites W1997720284 @default.
• W2110648151 cites W1998724633 @default.
• W2110648151 cites W1999744850 @default.
• W2110648151 cites W2001730407 @default.
• W2110648151 cites W2002352172 @default.
• W2110648151 cites W2012939708 @default.
• W2110648151 cites W2030267305 @default.
• W2110648151 cites W2047439787 @default.
• W2110648151 cites W2051452587 @default.
• W2110648151 cites W2055956984 @default.
• W2110648151 cites W2059265460 @default.
• W2110648151 cites W2062115941 @default.
• W2110648151 cites W2066054990 @default.
• W2110648151 cites W2066915061 @default.
• W2110648151 cites W2068518800 @default.
• W2110648151 cites W2073082596 @default.
• W2110648151 cites W2079050436 @default.
• W2110648151 cites W2082762584 @default.
• W2110648151 cites W2083605841 @default.
• W2110648151 cites W2086660631 @default.
• W2110648151 cites W2091151964 @default.
• W2110648151 cites W2091214947 @default.
• W2110648151 cites W2098104802 @default.
• W2110648151 cites W2101385560 @default.
• W2110648151 cites W2118076431 @default.
• W2110648151 cites W2123326107 @default.
• W2110648151 cites W2130566610 @default.
• W2110648151 cites W2136303131 @default.
• W2110648151 cites W2137417707 @default.
• W2110648151 cites W2137755719 @default.
• W2110648151 cites W2144295251 @default.
• W2110648151 cites W2144720497 @default.
• W2110648151 cites W2150261685 @default.
• W2110648151 cites W2152187155 @default.
• W2110648151 cites W2152221369 @default.
• W2110648151 cites W2156407587 @default.
• W2110648151 cites W2158930854 @default.
• W2110648151 cites W2160779871 @default.
• W2110648151 cites W2179803393 @default.
• W2110648151 doi "https://doi.org/10.1371/journal.pone.0022744" @default.
• W2110648151 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3144245" @default.
• W2110648151 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21818381" @default.
• W2110648151 hasPublicationYear "2011" @default.
• W2110648151 type Work @default.
• W2110648151 sameAs 2110648151 @default.
• W2110648151 citedByCount "7" @default.
• W2110648151 countsByYear W21106481512014 @default.
• W2110648151 countsByYear W21106481512017 @default.
• W2110648151 countsByYear W21106481512018 @default.
• W2110648151 countsByYear W21106481512019 @default.
• W2110648151 crossrefType "journal-article" @default.
• W2110648151 hasAuthorship W2110648151A5019700045 @default.
• W2110648151 hasAuthorship W2110648151A5070753307 @default.
• W2110648151 hasBestOaLocation W21106481511 @default.
• W2110648151 hasConcept C104317684 @default.
• W2110648151 hasConcept C119062480 @default.
• W2110648151 hasConcept C139447449 @default.
• W2110648151 hasConcept C142724271 @default.
• W2110648151 hasConcept C143065580 @default.
• W2110648151 hasConcept C158617107 @default.
• W2110648151 hasConcept C158619295 @default.
• W2110648151 hasConcept C204328495 @default.
• W2110648151 hasConcept C2775962898 @default.
• W2110648151 hasConcept C2777576037 @default.
• W2110648151 hasConcept C2779222958 @default.
• W2110648151 hasConcept C54355233 @default.
• W2110648151 hasConcept C57581600 @default.
• W2110648151 hasConcept C6492254 @default.
• W2110648151 hasConcept C71924100 @default.
• W2110648151 hasConcept C86803240 @default.
• W2110648151 hasConcept C95444343 @default.
• W2110648151 hasConceptScore W2110648151C104317684 @default.
• W2110648151 hasConceptScore W2110648151C119062480 @default.
• W2110648151 hasConceptScore W2110648151C139447449 @default.
• W2110648151 hasConceptScore W2110648151C142724271 @default.
• W2110648151 hasConceptScore W2110648151C143065580 @default.
• W2110648151 hasConceptScore W2110648151C158617107 @default.
• W2110648151 hasConceptScore W2110648151C158619295 @default.

• next