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• W2110648462 endingPage "6463" @default.
• W2110648462 startingPage "6457" @default.
• W2110648462 abstract "ABSTRACT Hepatitis delta virus (HDV) encodes one protein, hepatitis delta antigen (δAg), a 195-amino-acid RNA binding protein essential for the accumulation of HDV RNA-directed RNA transcripts. It has been accepted that δAg localizes predominantly to the nucleolus in the absence of HDV genome replication while in the presence of replication, δAg facilitates HDV RNA transport to the nucleoplasm and helps redirect host RNA polymerase II (Pol II) to achieve transcription and accumulation of processed HDV RNA species. This study used immunostaining and confocal microscopy to evaluate factors controlling the localization of δAg in the presence and absence of replicating and nonreplicating HDV RNAs. When δAg was expressed in the absence of full-length HDV RNAs, it colocalized with nucleolin, a predominant nucleolar protein. With time, or more quickly after induced cell stress, there was a redistribution of both δAg and nucleolin to the nucleoplasm. Following expression of nonreplicating HDV RNAs, δAg moved to the nucleoplasm, but nucleolin was unchanged. When δAg was expressed along with replicating HDV RNA, it was found predominantly in the nucleoplasm along with Pol II. This localization was insensitive to inhibitors of HDV replication, suggesting that the majority of δAg in the nucleoplasm reflects ribonucleoprotein accumulation rather than ongoing transcription. An additional approach was to reevaluate several forms of δAg altered at specific locations considered to be essential for protein function. These studies provide evidence that δAg does not interact directly with either Pol II or nucleolin and that forms of δAg which support replication are also capable of prior nucleolar transit." @default.
• W2110648462 created "2016-06-24" @default.
• W2110648462 creator A5053626350 @default.
• W2110648462 creator A5065074773 @default.
• W2110648462 creator A5067855923 @default.
• W2110648462 creator A5088766033 @default.
• W2110648462 date "2009-07-01" @default.
• W2110648462 modified "2023-09-26" @default.
• W2110648462 title "Intracellular Localization of Hepatitis Delta Virus Proteins in the Presence and Absence of Viral RNA Accumulation" @default.
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• W2110648462 doi "https://doi.org/10.1128/jvi.00008-09" @default.
• W2110648462 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2698582" @default.
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• W2110648462 hasPublicationYear "2009" @default.
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