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- W2110652086 abstract "<h3>Background</h3> High seroprevalence of human herpesvirus type 8 (HHV-8) in patients with cirrhosis has been reported to be associated with thrombocytopenia. Severe cirrhosis is always complicated with ascites. HHV-8 DNA levels in effusion from patients with primary effusion lymphoma has been reported to be significantly greater than in blood. The status of HHV-8 antibody and DNA in cirrhotic ascites is unclear. <h3>Aims</h3> To assess the status of HHV-8 antibody and DNA in cirrhotic ascites compared to that in cirrhotic plasma. <h3>Methods</h3> Plasma and ascites samples were collected from 85 patients with cirrhosis. HHV-8 antibody and DNA were detected by immunofluorescence assay and PCR, respectively. <h3>Results</h3> Male patients seropositive for HHV-8 antibody were significantly younger than seropositive female patients (p=0.0039). The seropositive rate in patients with cirrhosis was not associated with thrombocytopenia (p=0.6860). Both positive rate and titres of antibody in plasma were much greater than in ascites (p<0.0001). More male or Child–Pugh class C than female or class B seropositive patients were positive for ascites. No hepatitis C virus-related ascites were positive for antibody. Neither plasma nor ascites samples from any subject were positive for HHV-8 DNA. <h3>Conclusions</h3> In patients with cirrhosis, the seropositive rate for HHV-8 antibody is independent of thrombocytopenia. The positive rate for HHV-8 antibody in cirrhotic ascites seems to be associated with sex, disease severity and disease aetiology." @default.
- W2110652086 created "2016-06-24" @default.
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- W2110652086 date "2010-03-01" @default.
- W2110652086 modified "2023-10-17" @default.
- W2110652086 title "Human herpesvirus type 8 in patients with cirrhosis independent of thrombocytopenia" @default.
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- W2110652086 doi "https://doi.org/10.1136/jcp.2009.071621" @default.
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