FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110656070> ?p ?o ?g. }

• W2110656070 endingPage "1799" @default.
• W2110656070 startingPage "1789" @default.
• W2110656070 abstract "To address the relationship between viral and host factors during HIV infection, we analyzed the effect of viral mutations on T cell responses in seropositive, asymptomatic HLA-A2+ individuals using four envelope (env)-specific peptides with the HLA-A*0201 binding motif. We showed that the natural sequence variation was frequent within epitopes located in the C-terminal region of the env glycoprotein and was largely responsible for a lower env-specific cytotoxic T lymphocyte (CTL) activity in the peptide-stimulated cultures. The highest CTL responses in vitro were induced with conserved epitopes D1 and 4.3 that mapped to the N-terminal region of the env glycoprotein. These peptides exhibited high binding affinity for HLA-A*0201 molecules and stimulated CD8+ T cells of relatively limited TCR Vbeta chain repertoire. Decreased CTL activities to the D1 epitope were observed in the absence of any detectable viral mutation, and were associated with lower proliferative responses and expression of the CD28 antigen. Results of this study demonstrate that the degree of sequence variation within a stimulatory epitope of the viral quasispecies, as well as proliferative potential of the effector cells, are among the factors underlying decreased CTL activity in HIV-infected patients. These experiments also provide evidence that the D1 peptide might be useful for the development of vaccines and immune-based therapy." @default.
• W2110656070 created "2016-06-24" @default.
• W2110656070 creator A5008884652 @default.
• W2110656070 creator A5015588045 @default.
• W2110656070 creator A5019050712 @default.
• W2110656070 creator A5020401798 @default.
• W2110656070 creator A5022840218 @default.
• W2110656070 creator A5038253214 @default.
• W2110656070 creator A5050931159 @default.
• W2110656070 creator A5061834347 @default.
• W2110656070 creator A5066778078 @default.
• W2110656070 creator A5078546233 @default.
• W2110656070 creator A5082760150 @default.
• W2110656070 date "1998-12-01" @default.
• W2110656070 modified "2023-09-23" @default.
• W2110656070 title "The effect of epitope variation on the profile of cytotoxic T lymphocyte responses to the HIV envelope glycoprotein." @default.
• W2110656070 cites W1490953272 @default.
• W2110656070 cites W1505520677 @default.
• W2110656070 cites W1516856620 @default.
• W2110656070 cites W1536478289 @default.
• W2110656070 cites W1572054114 @default.
• W2110656070 cites W1602527453 @default.
• W2110656070 cites W1970205828 @default.
• W2110656070 cites W1986152436 @default.
• W2110656070 cites W1988707875 @default.
• W2110656070 cites W1996464851 @default.
• W2110656070 cites W1998045355 @default.
• W2110656070 cites W2002131798 @default.
• W2110656070 cites W2002667164 @default.
• W2110656070 cites W2037343680 @default.
• W2110656070 cites W2055875053 @default.
• W2110656070 cites W2066411387 @default.
• W2110656070 cites W2071459721 @default.
• W2110656070 cites W2079542677 @default.
• W2110656070 cites W2111259757 @default.
• W2110656070 cites W2114119969 @default.
• W2110656070 cites W2133402813 @default.
• W2110656070 cites W2136613244 @default.
• W2110656070 cites W2144956326 @default.
• W2110656070 cites W2146438815 @default.
• W2110656070 cites W2169404894 @default.
• W2110656070 cites W2336149973 @default.
• W2110656070 cites W2417991891 @default.
• W2110656070 doi "https://doi.org/10.1093/intimm/10.12.1789" @default.
• W2110656070 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9885899" @default.
• W2110656070 hasPublicationYear "1998" @default.
• W2110656070 type Work @default.
• W2110656070 sameAs 2110656070 @default.
• W2110656070 citedByCount "6" @default.
• W2110656070 crossrefType "journal-article" @default.
• W2110656070 hasAuthorship W2110656070A5008884652 @default.
• W2110656070 hasAuthorship W2110656070A5015588045 @default.
• W2110656070 hasAuthorship W2110656070A5019050712 @default.
• W2110656070 hasAuthorship W2110656070A5020401798 @default.
• W2110656070 hasAuthorship W2110656070A5022840218 @default.
• W2110656070 hasAuthorship W2110656070A5038253214 @default.
• W2110656070 hasAuthorship W2110656070A5050931159 @default.
• W2110656070 hasAuthorship W2110656070A5061834347 @default.
• W2110656070 hasAuthorship W2110656070A5066778078 @default.
• W2110656070 hasAuthorship W2110656070A5078546233 @default.
• W2110656070 hasAuthorship W2110656070A5082760150 @default.
• W2110656070 hasBestOaLocation W21106560701 @default.
• W2110656070 hasConcept C108625454 @default.
• W2110656070 hasConcept C147483822 @default.
• W2110656070 hasConcept C147969180 @default.
• W2110656070 hasConcept C153911025 @default.
• W2110656070 hasConcept C154317977 @default.
• W2110656070 hasConcept C159047783 @default.
• W2110656070 hasConcept C167672396 @default.
• W2110656070 hasConcept C195616568 @default.
• W2110656070 hasConcept C202751555 @default.
• W2110656070 hasConcept C203014093 @default.
• W2110656070 hasConcept C2776090121 @default.
• W2110656070 hasConcept C54355233 @default.
• W2110656070 hasConcept C86803240 @default.
• W2110656070 hasConcept C8891405 @default.
• W2110656070 hasConceptScore W2110656070C108625454 @default.
• W2110656070 hasConceptScore W2110656070C147483822 @default.
• W2110656070 hasConceptScore W2110656070C147969180 @default.
• W2110656070 hasConceptScore W2110656070C153911025 @default.
• W2110656070 hasConceptScore W2110656070C154317977 @default.
• W2110656070 hasConceptScore W2110656070C159047783 @default.
• W2110656070 hasConceptScore W2110656070C167672396 @default.
• W2110656070 hasConceptScore W2110656070C195616568 @default.
• W2110656070 hasConceptScore W2110656070C202751555 @default.
• W2110656070 hasConceptScore W2110656070C203014093 @default.
• W2110656070 hasConceptScore W2110656070C2776090121 @default.
• W2110656070 hasConceptScore W2110656070C54355233 @default.
• W2110656070 hasConceptScore W2110656070C86803240 @default.
• W2110656070 hasConceptScore W2110656070C8891405 @default.
• W2110656070 hasIssue "12" @default.
• W2110656070 hasLocation W21106560701 @default.
• W2110656070 hasLocation W21106560702 @default.
• W2110656070 hasOpenAccess W2110656070 @default.
• W2110656070 hasPrimaryLocation W21106560701 @default.
• W2110656070 hasRelatedWork W1513178816 @default.
• W2110656070 hasRelatedWork W2016031396 @default.
• W2110656070 hasRelatedWork W2018916009 @default.

• next