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- W2110663156 abstract "Background: Beta-(1-3),(1-6)-D-glucans demonstrate antitumor effects in vivo due to the activation of innate immune cells. Cyclophosphamide (CY) enhances natural or therapeutically induced antitumor immune responses by reducing the number and activity of regulatory T (Treg) cells. Materials and Methods: We tested whether oral administration of soluble beta-glucan augmented the inhibitory effect of intraperitoneally injected low-dose CY (30 mg/kg) on subcutaneously growing A20-lymphoma in Balb/c-mice. Results: Administration of CY one week after tumor inoculation significantly diminished tumor growth (p=0.009) and the absolute number of Treg cells in the peripheral blood compared with phosphate buffered saline- treated mice (p=0.036). Treatment of CY pre-conditioned lymphoma-bearing mice with daily beta-glucan (400 μg/mouse) between day 9 and day 13 after tumor injection significantly delayed onset of tumor growth, compared to mice which received only CY (p=0.01). Conclusion: Beta-(1- 3),(1-6)-D-glucan could be useful in the treatment of lymphoma after low-dose chemotherapy with CY. The treatment of tumor-bearing hosts with a combination of chemotherapeutic and immune-stimulatory agents receives increasing attention and is tested in numerous pre-clinical and clinical studies. Cyclophosphamide (CY) is a commonly used chemotherapeutic agent for the treatment of lymphomas and solid tumor malignancies. Besides its direct cytotoxic function on tumor cells, CY was shown to exert pronounced immune-modulatory effects by decreasing T suppressor cells, resetting dendritic cell (DC) maturation and strong induction of immune-activatory cytokines in the 'rebound phase' of" @default.
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- W2110663156 date "2011-04-01" @default.
- W2110663156 modified "2023-10-02" @default.
- W2110663156 title "Beta-(1-3),(1-6)-D-glucan Enhances the Effect of Low-dose Cyclophosphamide Treatment on A20 Lymphoma in Mice" @default.
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