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• W2110664037 abstract "Female Infertility Therapy, Current Practice provides comprehensive and up to date information on recent advances in infertility management. The text is 417 pages and includes contributions from 78 worldwide leading authorities in reproductive medicine. The text represents a collection of papers that compliments a Serono Symposium held in London in September 1998. The symposium marked the retirement of Professor Howard Jacobs. The book is divided into nine sections. Section one opens with data on fertility treatment and its effect on the fetus, pregnancy, and pregnancy outcome. The IVF and cancer risks are also discussed, providing results of a cohort study of 10,358 women registered for IVF at a leading program in Melbourne, Australia. The conclusion of this section provides a clear understanding of fertility medications and associated risks. Section two is a single chapter titled genetically determined reproductive dysfunction in women. This brief chapter reviews reproductive disorders arising from mutations in the GnRH, FSH, and LH receptor genes. Section three addresses basic science and clinical aspects of polycystic ovaries. The section opens with an introduction to the molecular genetics of polycystic ovary syndrome. Additional chapters review ovulation induction strategies and optimizing protocols. Both medical and surgical management strategies are reviewed. Novel approaches with the use of GnRH agonists are covered. This section provides the reader with a thorough review of the basic science surrounding polycystic ovary syndrome and an appreciation of the clinical complexity involved in the management of this disorder. Section four is dedicated to current practice with recombinant drugs. A wonderful background is provided on the evolution of gonadotropin therapy in assisted reproductive technologies. Basic knowledge about recombinant hormone production is provided. Authors review the use of recombinant FSH, LH, and hCG. Benefits along with limitations of recombinant FSH use in ovulation induction are reviewed. Caution is given for use in WHO group 1 anovulation. A nice review of the early studies with recombinant drugs in IVF is also covered. Section five is titled GnRH agonists and antagonists. Similar to section four this section begins by providing basic background about native GnRH and its agonistic and antagonistic analogues. Useful tables are provided. An interesting chapter takes a critical look at the doses of GnRH agonists used clinically to suppress the LH surge and to treat myomas. The authors provide provocative evidence that current doses for these indications could be reduced by 50%–80%. The pros and cons of the various GnRH agonist protocols in IVF—from ultrashort to ultralong—are reviewed. Also, current experience and protocols with GnRH antagonists in IVF are reviewed. Section six focuses on in vitro fertilization and micromanipulation. This section begins with a historical review of various micromanipulation methods. The evolution of the use of lasers for micromanipulation and the recent clinical uses for the 1.48-μm diode laser are explored. Additional chapters review basic principles surrounding cryopreservation, ICSI, in vitro maturation of human oocytes, and embryo culture. Research involving oocyte and ovarian tissue cryopreservation is discussed. Techniques to optimize outcome for oocyte and ovarian tissue cryopreservation are provided. Data are presented from 6 years of clinical practice with ICSI—6,200 ICSI procedures—from the program with the largest experience with this technique in Brussels, Belgium. An emphasis is made on appropriate counseling of all couples undergoing ICSI. A practical guide to IVM of human oocytes is elegantly and simply presented. Finally, this section addresses improving embryo culture and optimizing pregnancy rates. A concise review of the current practice of blastocyst culture and transfer is provided. Section seven explores the side effects of fertility treatment. The pathophysiology of ovarian hyperstimulation is reviewed. Strategies to prevent hyperstimulation including the use of IV albumin are discussed. Problems involved in multiple pregnancy are emphasized. A comprehensive update on fertility drugs and cancer risk is provided. The focus of section eight is endometriosis. The section begins with background on the disease pathophysiology. Other chapters review the principles behind medical and surgical management of endometriosis. The text concludes with a final section on implantation. The authors provide a review of the basic aspects of human implantation. Useful illustrations compliment the text. Current strategies to improve implantation rates are discussed. Methods for clinical assessment of uterine receptivity from histology to Doppler ultrasound of the uterine arteries are covered. In summary, this text is an exceptional authoritative review of Female Infertility Therapy, Current Practice. This text is recommended for reproductive scientists, fellows in reproductive medicine, allied health staff involved in infertility patient care, and anyone interested in an easy-to-read review of current fertility practice." @default.
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• W2110664037 title "Shoham Z, Howles CM, Jacobs HS, editors. female infertility therapy, current practice. London: Martin Dunitz, Ltd., 1999." @default.
• W2110664037 doi "https://doi.org/10.1016/s0015-0282(99)00445-8" @default.
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