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- W2110671985 abstract "The incidence of perioperative hypersensitivity reactions reported in the literature is highly variable, ranging from 1/1361 to 1/20000 procedures in different countries in Europe and Oceania. The aim of this study was to determine the incidence of allergic reactions during general anesthesia in Clinica Universidad de Navarra and to establish the frequency of the allergic reactions occurring for each of the drugs used. Patients suffering a reaction suggestive of hypersensitivity over a 30-month period (Feb-2008 to Aug-2010), that occurred during a procedure with general anesthesia and intubation or regional anesthesia with sedation were included. Prick and intradermal skin tests were performed. The study was approved by local Ethics Committee. A total of 16946 surgical procedures were performed (53% males, mean age 51,6 years). Forty-four perianesthetic reactions were recorded (ratio 1/385). Fifty-seven percent occurred during the induction of anesthesia (48% grade 1, 20% grade 2, 32% grade 3). Thirty-four percent had a rash as the sole manifestation, detecting an IgE-mediated mechanism in one-third of these. Five procedures (11%) were suspended given the severity of the reactions. Fifty percent were IgE-mediated reactions and in 7% a non-IgE agent was found (cold and NSAID-intolerance). Frequencies of reactions for different drugs were: protamine (1/468), cisatracurium (1/1388), amoxicillin-clavulanate (1/1968), atracurium (1/2039), dipyrone (1/3159). Perioperative reactions were more frequent than previously reported. It is important to perform an allergological study to all patients suffering suspicious hypersensitive perioperative reaction, including those with mild symptoms, since a substancial number are IgE-mediated reactions." @default.
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- W2110671985 date "2014-02-01" @default.
- W2110671985 modified "2023-10-18" @default.
- W2110671985 title "Perioperative Reactions: Are They So Infrequent?" @default.
- W2110671985 doi "https://doi.org/10.1016/j.jaci.2013.12.955" @default.
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