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• W2110682307 endingPage "7375" @default.
• W2110682307 startingPage "7368" @default.
• W2110682307 abstract "Motor learning is thought to involve modulation of synaptic inputs in the cerebellar cortex, including granule neuron/Purkinje neuron contacts. During a complex motor task requiring mice to walk across irregularly spaced pegs, cerebellar granule neurons show a rapid and transient induction of mRNA for the extracellular protease tissue plasminogen activator (tPA). This induction of tPA mRNA is cerebellar specific, is not seen in the cerebella of exercised or stressed animals, and is distinct from simple performance phenomena. Knock-out mice lacking the tPA gene show a significant reduction in both rate and extent of learning. Furthermore, blocking tPA activity during training dramatically impaired motor learning. Thus, tPA plays an important role in motor learning, in which tPA may facilitate remodeling of the active synaptic zone." @default.
• W2110682307 created "2016-06-24" @default.
• W2110682307 creator A5005602319 @default.
• W2110682307 creator A5045801275 @default.
• W2110682307 creator A5063058067 @default.
• W2110682307 date "2003-08-13" @default.
• W2110682307 modified "2023-10-14" @default.
• W2110682307 title "Absence of Tissue Plasminogen Activator Gene or Activity Impairs Mouse Cerebellar Motor Learning" @default.
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• W2110682307 doi "https://doi.org/10.1523/jneurosci.23-19-07368.2003" @default.
• W2110682307 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6740439" @default.
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