FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110688076> ?p ?o ?g. }

• W2110688076 endingPage "1908" @default.
• W2110688076 startingPage "1900" @default.
• W2110688076 abstract "Survival in patients with systemic sclerosis (SSc)-associated pulmonary hypertension (PH) and interstitial lung disease (ILD) is poor. Evidence supporting the efficacy of aggressive pulmonary arterial hypertension (PAH)-targeted therapy in this population is limited. The aim of this study was to investigate transplant-free survival in patients with isolated SSc-related PAH or SSc-related PH-ILD who were treated with aggressive PAH-targeted therapy.SSc patients with right-sided heart catheterization (RHC)-diagnosed precapillary PH (mean pulmonary artery pressure ≥25 mm Hg, pulmonary capillary wedge pressure ≤15 mm Hg, and pulmonary vascular resistance ≥240 dynes × second/cm(5) ) were included. Patients were classified as having ILD based on review of high-resolution computed tomography (CT) chest imaging and spirometry. The Kaplan-Meier method was applied and Cox proportional hazards models were constructed to analyze survival and identify predictive variables.Of 99 patients with SSc-related precapillary PH, 28% had SSc-related PAH and 72% had SSc-related PH-ILD. The 1- and 2-year survival estimates were, respectively, 72% and 59% in the SSc-related PH-ILD group versus 82% and 66% in the SSc-related PAH group (P = 0.5). Within 6 months of the diagnostic RHC, 24% of all patients were started on prostanoid therapy; an additional 24% were started on prostanoid therapy after 6 months. In the multivariate model, male sex (hazard ratio [HR] 0.7, P = 0.01) and prostanoid therapy initiation within 6 months of the RHC (HR 1.4, P = 0.01) were the only factors significantly associated with transplant-free survival, after accounting for the presence of ILD and severity of PH.In this study, survival of patients with SSc-related PH-ILD was modestly improved relative to historical series. While these findings may not be generalizable, improved survival may be due partly to aggressive PAH-targeted therapy." @default.
• W2110688076 created "2016-06-24" @default.
• W2110688076 creator A5001684279 @default.
• W2110688076 creator A5009560818 @default.
• W2110688076 creator A5013508752 @default.
• W2110688076 creator A5018731653 @default.
• W2110688076 creator A5025906021 @default.
• W2110688076 creator A5039783745 @default.
• W2110688076 creator A5049324725 @default.
• W2110688076 creator A5052689722 @default.
• W2110688076 creator A5056836366 @default.
• W2110688076 creator A5059206584 @default.
• W2110688076 creator A5067493084 @default.
• W2110688076 creator A5072335131 @default.
• W2110688076 creator A5073269240 @default.
• W2110688076 date "2014-06-27" @default.
• W2110688076 modified "2023-10-17" @default.
• W2110688076 title "Improved Transplant-Free Survival in Patients With Systemic Sclerosis-Associated Pulmonary Hypertension and Interstitial Lung Disease" @default.
• W2110688076 cites W1985526821 @default.
• W2110688076 cites W1999594706 @default.
• W2110688076 cites W2003012980 @default.
• W2110688076 cites W2005131496 @default.
• W2110688076 cites W2019515096 @default.
• W2110688076 cites W2035384054 @default.
• W2110688076 cites W2042113729 @default.
• W2110688076 cites W2048940287 @default.
• W2110688076 cites W2060542850 @default.
• W2110688076 cites W2064446419 @default.
• W2110688076 cites W2070897020 @default.
• W2110688076 cites W2076198557 @default.
• W2110688076 cites W2083401634 @default.
• W2110688076 cites W2094957167 @default.
• W2110688076 cites W2100418954 @default.
• W2110688076 cites W2116531828 @default.
• W2110688076 cites W2119616697 @default.
• W2110688076 cites W2127247740 @default.
• W2110688076 cites W2130932769 @default.
• W2110688076 cites W2135510321 @default.
• W2110688076 cites W2143819380 @default.
• W2110688076 cites W2144822715 @default.
• W2110688076 cites W2146438051 @default.
• W2110688076 cites W2150226364 @default.
• W2110688076 cites W2159214565 @default.
• W2110688076 cites W2160626307 @default.
• W2110688076 cites W4293178741 @default.
• W2110688076 doi "https://doi.org/10.1002/art.38623" @default.
• W2110688076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24729406" @default.
• W2110688076 hasPublicationYear "2014" @default.
• W2110688076 type Work @default.
• W2110688076 sameAs 2110688076 @default.
• W2110688076 citedByCount "38" @default.
• W2110688076 countsByYear W21106880762013 @default.
• W2110688076 countsByYear W21106880762014 @default.
• W2110688076 countsByYear W21106880762015 @default.
• W2110688076 countsByYear W21106880762016 @default.
• W2110688076 countsByYear W21106880762017 @default.
• W2110688076 countsByYear W21106880762018 @default.
• W2110688076 countsByYear W21106880762019 @default.
• W2110688076 countsByYear W21106880762020 @default.
• W2110688076 countsByYear W21106880762021 @default.
• W2110688076 countsByYear W21106880762022 @default.
• W2110688076 countsByYear W21106880762023 @default.
• W2110688076 crossrefType "journal-article" @default.
• W2110688076 hasAuthorship W2110688076A5001684279 @default.
• W2110688076 hasAuthorship W2110688076A5009560818 @default.
• W2110688076 hasAuthorship W2110688076A5013508752 @default.
• W2110688076 hasAuthorship W2110688076A5018731653 @default.
• W2110688076 hasAuthorship W2110688076A5025906021 @default.
• W2110688076 hasAuthorship W2110688076A5039783745 @default.
• W2110688076 hasAuthorship W2110688076A5049324725 @default.
• W2110688076 hasAuthorship W2110688076A5052689722 @default.
• W2110688076 hasAuthorship W2110688076A5056836366 @default.
• W2110688076 hasAuthorship W2110688076A5059206584 @default.
• W2110688076 hasAuthorship W2110688076A5067493084 @default.
• W2110688076 hasAuthorship W2110688076A5072335131 @default.
• W2110688076 hasAuthorship W2110688076A5073269240 @default.
• W2110688076 hasBestOaLocation W21106880762 @default.
• W2110688076 hasConcept C126322002 @default.
• W2110688076 hasConcept C141071460 @default.
• W2110688076 hasConcept C142724271 @default.
• W2110688076 hasConcept C146556889 @default.
• W2110688076 hasConcept C164705383 @default.
• W2110688076 hasConcept C180032290 @default.
• W2110688076 hasConcept C207103383 @default.
• W2110688076 hasConcept C2777543607 @default.
• W2110688076 hasConcept C2777714996 @default.
• W2110688076 hasConcept C2779967694 @default.
• W2110688076 hasConcept C2780930700 @default.
• W2110688076 hasConcept C2780940725 @default.
• W2110688076 hasConcept C2781448352 @default.
• W2110688076 hasConcept C2908647359 @default.
• W2110688076 hasConcept C44249647 @default.
• W2110688076 hasConcept C50382708 @default.
• W2110688076 hasConcept C71924100 @default.
• W2110688076 hasConcept C90924648 @default.
• W2110688076 hasConcept C99454951 @default.
• W2110688076 hasConceptScore W2110688076C126322002 @default.
• W2110688076 hasConceptScore W2110688076C141071460 @default.

• next