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• W2110688302 abstract "We describe the development of multifunctional polymeric micelles with cancer-targeting capability via alpha(v)beta(3) integrins, controlled drug delivery, and efficient magnetic resonance imaging (MRI) contrast characteristics. Doxorubicin and a cluster of superparamagnetic iron oxide (SPIO) nanoparticles were loaded successfully inside the micelle core. The presence of cRGD on the micelle surface resulted in the cancer-targeted delivery to alpha(v)beta(3)-expressing tumor cells. In vitro MRI and cytotoxicity studies demonstrated the ultrasensitive MRI imaging and alpha(v)beta(3)-specific cytotoxic response of these multifunctional polymeric micelles." @default.
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• W2110688302 date "2006-10-24" @default.
• W2110688302 modified "2023-09-30" @default.
• W2110688302 title "Multifunctional Polymeric Micelles as Cancer-Targeted, MRI-Ultrasensitive Drug Delivery Systems" @default.
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• W2110688302 doi "https://doi.org/10.1021/nl061412u" @default.
• W2110688302 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17090068" @default.
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