Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110696892> ?p ?o ?g. }
- W2110696892 endingPage "218" @default.
- W2110696892 startingPage "206" @default.
- W2110696892 abstract "Summary: Although it is appreciated that the antigen receptor on B cells is required for peripheral B‐lymphocyte development and survival, it has been unclear whether this receptor interacts with self‐antigens during development or if it signals constitutively in an antigen‐independent fashion. The analysis of mutant mice in which antigen receptor signaling in B cells is either attenuated or enhanced has revealed the existence of a follicular versus marginal zone B‐lymphocyte cell‐fate decision. These analyses indicate that weak antigen receptor‐derived signals favor marginal zone B‐cell generation, and relatively strong signals favor the development of mature follicular B cells. Even stronger signals derived from the antigen receptor favor the generation of B1 B cells. This signal strength model for B‐cell development supports the notion that self‐antigens of varying affinity may mediate positive selection and lineage commitment. Direct evidence supporting such a view has been obtained from the analysis of antigen receptor knockin mice. Specific antigen receptors guide B cells to develop into specific lineages. Although Notch‐2, nuclear factor‐κBp50, and other genes are essential for marginal zone B‐cell development, instructive signals delivered by the antigen receptor represent the primary force driving positive selection and lineage commitment in B lymphocytes." @default.
- W2110696892 created "2016-06-24" @default.
- W2110696892 creator A5017686788 @default.
- W2110696892 creator A5064199086 @default.
- W2110696892 creator A5069840184 @default.
- W2110696892 date "2004-01-06" @default.
- W2110696892 modified "2023-10-12" @default.
- W2110696892 title "Positive selection and lineage commitment during peripheral B-lymphocyte development" @default.
- W2110696892 cites W1501881225 @default.
- W2110696892 cites W1504988690 @default.
- W2110696892 cites W1524949022 @default.
- W2110696892 cites W1537427513 @default.
- W2110696892 cites W1553815101 @default.
- W2110696892 cites W1561493617 @default.
- W2110696892 cites W1585256292 @default.
- W2110696892 cites W1666780611 @default.
- W2110696892 cites W1810839417 @default.
- W2110696892 cites W1849784454 @default.
- W2110696892 cites W1964456603 @default.
- W2110696892 cites W1966408108 @default.
- W2110696892 cites W1974224187 @default.
- W2110696892 cites W1975225711 @default.
- W2110696892 cites W1976176890 @default.
- W2110696892 cites W1977049778 @default.
- W2110696892 cites W1978019581 @default.
- W2110696892 cites W1979977043 @default.
- W2110696892 cites W1981628302 @default.
- W2110696892 cites W1984654649 @default.
- W2110696892 cites W1990045258 @default.
- W2110696892 cites W2003131704 @default.
- W2110696892 cites W2012751406 @default.
- W2110696892 cites W2013217534 @default.
- W2110696892 cites W2016591994 @default.
- W2110696892 cites W2022157262 @default.
- W2110696892 cites W2023898808 @default.
- W2110696892 cites W2025755006 @default.
- W2110696892 cites W2030538685 @default.
- W2110696892 cites W2035277099 @default.
- W2110696892 cites W2036068614 @default.
- W2110696892 cites W2037951817 @default.
- W2110696892 cites W2039490597 @default.
- W2110696892 cites W2041572974 @default.
- W2110696892 cites W2042295852 @default.
- W2110696892 cites W2042379617 @default.
- W2110696892 cites W2043186109 @default.
- W2110696892 cites W2045641853 @default.
- W2110696892 cites W2046211031 @default.
- W2110696892 cites W2054458458 @default.
- W2110696892 cites W2055591498 @default.
- W2110696892 cites W2056611698 @default.
- W2110696892 cites W2056807976 @default.
- W2110696892 cites W2057191463 @default.
- W2110696892 cites W2057583981 @default.
- W2110696892 cites W2058074942 @default.
- W2110696892 cites W2060019843 @default.
- W2110696892 cites W2060390249 @default.
- W2110696892 cites W2063229662 @default.
- W2110696892 cites W2063825367 @default.
- W2110696892 cites W2066177415 @default.
- W2110696892 cites W2071981946 @default.
- W2110696892 cites W2075626786 @default.
- W2110696892 cites W2079232338 @default.
- W2110696892 cites W2079683161 @default.
- W2110696892 cites W2088549138 @default.
- W2110696892 cites W2091259187 @default.
- W2110696892 cites W2093577878 @default.
- W2110696892 cites W2095914822 @default.
- W2110696892 cites W2097604076 @default.
- W2110696892 cites W2100034730 @default.
- W2110696892 cites W2101094735 @default.
- W2110696892 cites W2103690233 @default.
- W2110696892 cites W2103944436 @default.
- W2110696892 cites W2106665711 @default.
- W2110696892 cites W2106840540 @default.
- W2110696892 cites W2107912726 @default.
- W2110696892 cites W2112622667 @default.
- W2110696892 cites W2113764179 @default.
- W2110696892 cites W2115732428 @default.
- W2110696892 cites W2117001717 @default.
- W2110696892 cites W2129793206 @default.
- W2110696892 cites W2134544592 @default.
- W2110696892 cites W2135701801 @default.
- W2110696892 cites W2138302399 @default.
- W2110696892 cites W2144935474 @default.
- W2110696892 cites W2146513661 @default.
- W2110696892 cites W2147507133 @default.
- W2110696892 cites W2147936520 @default.
- W2110696892 cites W2148591986 @default.
- W2110696892 cites W2150292882 @default.
- W2110696892 cites W2151546344 @default.
- W2110696892 cites W2155471228 @default.
- W2110696892 cites W2156239323 @default.
- W2110696892 cites W2159403435 @default.
- W2110696892 cites W2159722075 @default.
- W2110696892 cites W2163127671 @default.
- W2110696892 cites W2164964449 @default.
- W2110696892 cites W2170875982 @default.
- W2110696892 cites W2171833659 @default.