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• W2110712267 abstract "Significance Poly (ADP-ribose) (PAR) participates in initiating parthanatos, cell death mediated by apoptosis-inducing factor (AIF), following genotoxic stress. PAR translocation from the nucleus to cytoplasm is an essential step for AIF-mediated cell death. Here, we report that poly (ADP-ribose) glycohydrolase (PARG) enhances PAR translocation by releasing protein-free PAR fragments from nuclear acceptor proteins. ADP-ribosyl-acceptor hydrolase (ARH) 3 lowers PAR levels in the nucleus and cytoplasm, preventing PAR translocation and then parthanatos. Elucidation of the sequential action of PARG and ARH3 in the PAR-mediated pathway provides a better understanding of mechanisms underlying oxidative stress and may lead to new therapeutic targets." @default.
• W2110712267 created "2016-06-24" @default.
• W2110712267 creator A5003966461 @default.
• W2110712267 creator A5048042168 @default.
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• W2110712267 date "2013-11-04" @default.
• W2110712267 modified "2023-10-16" @default.
• W2110712267 title "ADP-ribosyl-acceptor hydrolase 3 regulates poly (ADP-ribose) degradation and cell death during oxidative stress" @default.
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• W2110712267 doi "https://doi.org/10.1073/pnas.1312783110" @default.
• W2110712267 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3839768" @default.
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• W2110712267 hasPublicationYear "2013" @default.
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