FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110722295> ?p ?o ?g. }

• W2110722295 endingPage "87" @default.
• W2110722295 startingPage "87" @default.
• W2110722295 abstract "PURPOSE: Loss of function or expression of the mismatch repair protein MLH1 and the tumor suppressor protein p53 have been implicated in acquired resistance to anticancer drugs. We have compared the expression of MLH1 and p53 in tumors from women with clinically node-positive breast cancer before and after primary (neoadjuvant) chemotherapy. Further, we have assessed the value of these markers as predictors of response to therapy by correlation with disease-free survival. PATIENTS AND METHODS: Immunohistochemistry scores of MLH1 and p53 expression were made on 36 tru-cut prechemotherapy biopsies and 29 paired postchemotherapy tumor samples. The significance of the change in scores and their correlation with disease-free survival were evaluated by the Wilcoxon signed rank sum test and Cox proportional hazards regression analysis, respectively. RESULTS: Primary chemotherapy results in a significant reduction in the percent of cells expressing MLH1 (P = .010). This change in MLH1 expression after chemotherapy is strongly associated with poor disease-free survival (P = .0025). Expression of p53 was not significantly altered by chemotherapy. Neither MLH1 nor p53 expression before chemotherapy predicted disease-free survival or tumor response to chemotherapy. Low MLH1 expression after chemotherapy was an independent predictor of poor disease-free survival on multivariate Cox analysis when considered with other clinicopathologic prognostic factors. CONCLUSION: Tumor cells that have reduced MLH1 expression seem to have a survival advantage during combined chemotherapy of locally advanced breast cancers, which supports the hypothesis that loss of MLH1 has a role in drug resistance. MLH1 expression after chemotherapy is an independent predictive factor for poor disease-free survival and may, therefore, define a group of patients with drug-resistant breast cancer." @default.
• W2110722295 created "2016-06-24" @default.
• W2110722295 creator A5004701734 @default.
• W2110722295 creator A5007286394 @default.
• W2110722295 creator A5049940232 @default.
• W2110722295 creator A5053758493 @default.
• W2110722295 creator A5057285559 @default.
• W2110722295 creator A5057815390 @default.
• W2110722295 creator A5074809942 @default.
• W2110722295 date "2000-01-01" @default.
• W2110722295 modified "2023-09-26" @default.
• W2110722295 title "Reduced MLH1 Expression in Breast Tumors After Primary Chemotherapy Predicts Disease-Free Survival" @default.
• W2110722295 cites W1754020298 @default.
• W2110722295 cites W1949597673 @default.
• W2110722295 cites W1962197769 @default.
• W2110722295 cites W1963581476 @default.
• W2110722295 cites W1966159870 @default.
• W2110722295 cites W1970731925 @default.
• W2110722295 cites W1976775167 @default.
• W2110722295 cites W1980076677 @default.
• W2110722295 cites W1982517685 @default.
• W2110722295 cites W1982640212 @default.
• W2110722295 cites W1991512313 @default.
• W2110722295 cites W2000557631 @default.
• W2110722295 cites W2009108669 @default.
• W2110722295 cites W2020275763 @default.
• W2110722295 cites W2024487324 @default.
• W2110722295 cites W2025959372 @default.
• W2110722295 cites W2027126449 @default.
• W2110722295 cites W2037920455 @default.
• W2110722295 cites W2053502729 @default.
• W2110722295 cites W2062421538 @default.
• W2110722295 cites W2064367468 @default.
• W2110722295 cites W206480088 @default.
• W2110722295 cites W2082504682 @default.
• W2110722295 cites W2098567881 @default.
• W2110722295 cites W2103489107 @default.
• W2110722295 cites W2107972234 @default.
• W2110722295 cites W2111703821 @default.
• W2110722295 cites W2133408654 @default.
• W2110722295 cites W2137075269 @default.
• W2110722295 cites W2317234826 @default.
• W2110722295 doi "https://doi.org/10.1200/jco.2000.18.1.87" @default.
• W2110722295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10623697" @default.
• W2110722295 hasPublicationYear "2000" @default.
• W2110722295 type Work @default.
• W2110722295 sameAs 2110722295 @default.
• W2110722295 citedByCount "89" @default.
• W2110722295 countsByYear W21107222952012 @default.
• W2110722295 countsByYear W21107222952013 @default.
• W2110722295 countsByYear W21107222952014 @default.
• W2110722295 countsByYear W21107222952015 @default.
• W2110722295 countsByYear W21107222952016 @default.
• W2110722295 countsByYear W21107222952017 @default.
• W2110722295 countsByYear W21107222952018 @default.
• W2110722295 countsByYear W21107222952019 @default.
• W2110722295 countsByYear W21107222952020 @default.
• W2110722295 countsByYear W21107222952023 @default.
• W2110722295 crossrefType "journal-article" @default.
• W2110722295 hasAuthorship W2110722295A5004701734 @default.
• W2110722295 hasAuthorship W2110722295A5007286394 @default.
• W2110722295 hasAuthorship W2110722295A5049940232 @default.
• W2110722295 hasAuthorship W2110722295A5053758493 @default.
• W2110722295 hasAuthorship W2110722295A5057285559 @default.
• W2110722295 hasAuthorship W2110722295A5057815390 @default.
• W2110722295 hasAuthorship W2110722295A5074809942 @default.
• W2110722295 hasConcept C10515644 @default.
• W2110722295 hasConcept C111425858 @default.
• W2110722295 hasConcept C121608353 @default.
• W2110722295 hasConcept C126322002 @default.
• W2110722295 hasConcept C143998085 @default.
• W2110722295 hasConcept C2776694085 @default.
• W2110722295 hasConcept C502942594 @default.
• W2110722295 hasConcept C50382708 @default.
• W2110722295 hasConcept C526805850 @default.
• W2110722295 hasConcept C530470458 @default.
• W2110722295 hasConcept C60748783 @default.
• W2110722295 hasConcept C71924100 @default.
• W2110722295 hasConceptScore W2110722295C10515644 @default.
• W2110722295 hasConceptScore W2110722295C111425858 @default.
• W2110722295 hasConceptScore W2110722295C121608353 @default.
• W2110722295 hasConceptScore W2110722295C126322002 @default.
• W2110722295 hasConceptScore W2110722295C143998085 @default.
• W2110722295 hasConceptScore W2110722295C2776694085 @default.
• W2110722295 hasConceptScore W2110722295C502942594 @default.
• W2110722295 hasConceptScore W2110722295C50382708 @default.
• W2110722295 hasConceptScore W2110722295C526805850 @default.
• W2110722295 hasConceptScore W2110722295C530470458 @default.
• W2110722295 hasConceptScore W2110722295C60748783 @default.
• W2110722295 hasConceptScore W2110722295C71924100 @default.
• W2110722295 hasIssue "1" @default.
• W2110722295 hasLocation W21107222951 @default.
• W2110722295 hasLocation W21107222952 @default.
• W2110722295 hasOpenAccess W2110722295 @default.
• W2110722295 hasPrimaryLocation W21107222951 @default.
• W2110722295 hasRelatedWork W2348231456 @default.
• W2110722295 hasRelatedWork W2354050160 @default.
• W2110722295 hasRelatedWork W2367105124 @default.

• next