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- W2110731034 abstract "In the nematode worm C. elegans, individuals with mutations in the spe-9 gene produce spermatozoa with wild-type morphology and motility that cannot fertilize oocytes even after contact between gametes. Therefore, disruption of spe-9 function affects either gamete recognition, adhesion, signaling, and/or fusion. The spe-9 gene encodes a sperm transmembrane protein with an extracellular domain that contains ten epidermal growth factor–like repeats. A common feature of proteins that include epidermal growth factor–like motifs is their involvement in extracellular functions such as adhesive and ligand–receptor interactions. Additionally, the overall structure of the predicted SPE-9 protein is similar to that of ligands for the Notch/LIN-12/GLP-1 family of transmembrane receptors. These results suggest that SPE-9 functions in the specialized cell–cell interactions required for fertilization." @default.
- W2110731034 created "2016-06-24" @default.
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- W2110731034 date "1998-04-01" @default.
- W2110731034 modified "2023-10-12" @default.
- W2110731034 title "The C. elegans spe-9 Gene Encodes a Sperm Transmembrane Protein that Contains EGF-like Repeats and Is Required for Fertilization" @default.
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- W2110731034 doi "https://doi.org/10.1016/s0092-8674(00)81147-2" @default.
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