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• W2110744564 endingPage "1055" @default.
• W2110744564 startingPage "1042" @default.
• W2110744564 abstract "ABSTRACT The hemolytic Streptococcus pyogenes can use a variety of heme compounds as an iron source. In this study, we investigate hemoprotein utilization by S. pyogenes . We demonstrate that surface proteins contribute to the binding of hemoproteins to S. pyogenes . We identify an ABC transporter from the iron complex family named sia for streptococcal iron acquisition, which consists of a lipoprotein ( siaA ), membrane permease ( siaB ), and ATPase ( siaC ). The sia transporter is part of a highly conserved, iron regulated, 10-gene operon. SiaA, which was localized to the cell membrane, could specifically bind hemoglobin. The operon's first gene encodes a novel bacterial protein that bound hemoglobin, myoglobin, heme-albumin, and hemoglobin-haptoglobin (but not apo-haptoglobin) and therefore was named Shr, for streptococcal hemoprotein receptor. PhoZ fusion and Western blot analysis showed that Shr has a leader peptide and is found in both membrane-bound and soluble forms. An M1 SF370 strain with a polar mutation in shr was more resistant to streptonigrin and hydrogen peroxide, suggesting decreased iron uptake. The addition of hemoglobin to the culture medium increased cell resistance to hydrogen peroxide in SF370 but not in the mutant, implying the sia operon may be involved in hemoglobin-dependent resistance to oxidative stress. The shr mutant demonstrated reduced hemoglobin binding, though cell growth in iron-depleted medium supplemented with hemoglobin, whole blood, or ferric citrate was not affected, suggesting additional systems are involved in hemoglobin utilization. SiaA and Shr are the first hemoprotein receptors identified in S. pyogenes ; their possible role in iron capture is discussed." @default.
• W2110744564 created "2016-06-24" @default.
• W2110744564 creator A5004932167 @default.
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• W2110744564 creator A5062395189 @default.
• W2110744564 creator A5070261420 @default.
• W2110744564 creator A5081604129 @default.
• W2110744564 date "2003-03-01" @default.
• W2110744564 modified "2023-09-23" @default.
• W2110744564 title "Identification and Characterization of a <i>Streptococcus pyogenes</i> Operon Involved in Binding of Hemoproteins and Acquisition of Iron" @default.
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• W2110744564 doi "https://doi.org/10.1128/iai.71.3.1042-1055.2003" @default.
• W2110744564 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/148835" @default.
• W2110744564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12595414" @default.
• W2110744564 hasPublicationYear "2003" @default.
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