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- W2110750374 abstract "To address insulin insufficiency, diabetes research has long focused on techniques for replacing insulin-producing β cells. Studies in mice have suggested that, under some conditions, α cells possess the capacity to transdifferentiate into β cells, although the mechanisms that drive this conversion are unclear. In this issue, Bramswig et al. analyzed the methylation states of purified human α, β, and acinar cells and found α cells exhibit intrinsic phenotypic plasticity associated with specific histone methylation profiles. In addition to expanding our understanding of this potential source of β cells, this compendium of carefully generated human gene expression and epigenomic data in islet cell subtypes constitutes a truly valuable resource for the field." @default.
- W2110750374 created "2016-06-24" @default.
- W2110750374 creator A5069357372 @default.
- W2110750374 date "2013-02-22" @default.
- W2110750374 modified "2023-09-23" @default.
- W2110750374 title "Creating new β cells: cellular transmutation by genomic alchemy" @default.
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- W2110750374 doi "https://doi.org/10.1172/jci68348" @default.
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