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• W2110752603 abstract "To decipher the mechanistic roles of Mediator proteins in regulating developmental specific gene expression and compare them to those of TATA-binding protein (TBP)-associated factors (TAFs), we isolated and analyzed a multiprotein complex containing Drosophila Mediator (dMediator) homologs. dMediator interacts with several sequence-specific transcription factors and basal transcription machinery and is critical for activated transcription in response to diverse transcriptional activators. The requirement for dMediator did not depend on a specific core promoter organization. By contrast, TAFs are preferentially utilized by promoters having a specific core element organization. Therefore, Mediator proteins are suggested to act as a pivotal coactivator that integrates promoter-specific activation signals to the basal transcription machinery." @default.
• W2110752603 created "2016-06-24" @default.
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• W2110752603 date "2001-04-01" @default.
• W2110752603 modified "2023-10-11" @default.
• W2110752603 title "Drosophila Mediator Complex Is Broadly Utilized by Diverse Gene-Specific Transcription Factors at Different Types of Core Promoters" @default.
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• W2110752603 doi "https://doi.org/10.1128/mcb.21.7.2312-2323.2001" @default.
• W2110752603 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/86865" @default.
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