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• W2110755004 endingPage "1217" @default.
• W2110755004 startingPage "1208" @default.
• W2110755004 abstract "We investigated the roles of sensory and noradrenergic sympathetic nerves on the cutaneous vasodilator response to a localized noxious heating stimulus. In two separate studies, four forearm skin sites were instrumented with microdialysis fibres, local heaters and laser-Doppler probes. Skin sites were locally heated from 33 to 42°C or rapidly to 44°C (noxious). In the first study, we tested sensory nerve involvement using EMLA cream. Treatments were as follows: (1) control 42°C; (2) EMLA 42°C; (3) control 44°C; and (4) EMLA 44°C. At the EMLA-treated sites, the axon reflex was reduced compared with the control sites during heating to 42°C (P < 0.05). There were no differences during the plateau phase (P > 0.05). At both the sites heated to 44°C, the initial peak and nadir became indistinguishable, and the EMLA-treated sites were lower compared with the control sites during the plateau phase (P < 0.05). In the second study, we tested the involvement of noradrenergic sympathetic nerves in response to the noxious heating using bretylium tosylate (BT). Treatments were as follows: (1) control 42°C; (2) BT 42°C; (3) control 44°C; and (4) BT 44°C. Treatment with BT at the 42°C sites resulted in a marked reduction in both the axon reflex and the secondary plateau (P < 0.05). At the 44°C sites, there was no apparent initial peak or nadir, but the plateau phase was reduced at the BT-treated sites (P < 0.05). These data suggest that both sympathetic nerves and sensory nerves are involved during the vasodilator response to a noxious heat stimulus." @default.
• W2110755004 created "2016-06-24" @default.
• W2110755004 creator A5023999932 @default.
• W2110755004 creator A5075568652 @default.
• W2110755004 date "2011-10-03" @default.
• W2110755004 modified "2023-10-17" @default.
• W2110755004 title "Sensory and sympathetic nerve contributions to the cutaneous vasodilator response from a noxious heat stimulus" @default.
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• W2110755004 doi "https://doi.org/10.1113/expphysiol.2011.059907" @default.
• W2110755004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21890519" @default.
• W2110755004 hasPublicationYear "2011" @default.
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