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• W2110779366 abstract "<h3>Aim</h3> To study tissue remodelling and wound healing after retinal pigment epithelium (RPE) tears due to age-related macular degeneration. <h3>Methods</h3> Retrospective longitudinal study of 36 eyes (33 patients) with RPE tears. Imaging was performed using fundus autofluorescence (FAF) (λ=488 nm) and spectral-domain optical coherence tomography (SD-OCT). Presence of intraretinal hyper-reflective dots in SD-OCT, which correlated with hyperfluorescent dots in FAF, indicating RPE migration was studied. Morphology of subretinal mass and RPE layer integrity in the RPE denuded area over time were examined. <h3>Results</h3> 7 of 36 eyes (19.4%) showed patchy or hazy hyperfluorescent areas in FAF, and the majority of eyes (83.3%) showed hyper-reflective dots, which possibly represent intraretinal RPE migration and hard exudates. Homogenous subretinal mass was encountered in about half of all cases. In one case (2.8%), the RPE layer proliferated and covered the defect. <h3>Conclusions</h3> SD-OCT and FAF showed a considerable amount of RPE proliferation, migration and repopulation. Intraretinal RPE migration did not form a functional RPE layer. A small defect might be repaired by cell proliferation. But this RPE proliferation is not sufficient to cover large defects." @default.
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• W2110779366 date "2012-07-23" @default.
• W2110779366 modified "2023-09-25" @default.
• W2110779366 title "Fundus autofluorescence and spectral-domain optical coherence tomography findings suggesting tissue remodelling in retinal pigment epithelium tear" @default.
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• W2110779366 doi "https://doi.org/10.1136/bjophthalmol-2012-301750" @default.
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