FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110789683> ?p ?o ?g. }

• W2110789683 endingPage "5531" @default.
• W2110789683 startingPage "5519" @default.
• W2110789683 abstract "Abstract The extensive involvement of miRNAs in cancer pathobiology has opened avenues for drug development based on oncomir inhibition. Dicer is the core enzyme in miRNA processing that cleaves the terminal loop of precursor microRNAs (pre-miRNAs) to generate mature miRNA duplexes. Using the three-dimensional structure of the Dicer binding site on the pre-miR-21 oncomir, we conducted an in silico high-throughput screen for small molecules that block miR-21 maturation. By this method, we identified a specific small-molecule inhibitor of miR-21, termed AC1MMYR2, which blocked the ability of Dicer to process pre-miR-21 to mature miR-21. AC1MMYR2 upregulated expression of PTEN, PDCD4, and RECK and reversed epithelial–mesenchymal transition via the induction of E-cadherin expression and the downregulation of mesenchymal markers, thereby suppressing proliferation, survival, and invasion in glioblastoma, breast cancer, and gastric cancer cells. As a single agent in vivo, AC1MMYR2 repressed tumor growth, invasiveness, and metastasis, increasing overall host survival with no observable tissue cytotoxicity in orthotopic models. Our results offer a novel, high-throughput method to screen for small-molecule inhibitors of miRNA maturation, presenting AC1MMYR2 as a broadly useful candidate antitumor drug. Cancer Res; 73(17); 5519–31. ©2013 AACR." @default.
• W2110789683 created "2016-06-24" @default.
• W2110789683 creator A5007814846 @default.
• W2110789683 creator A5016196534 @default.
• W2110789683 creator A5018122772 @default.
• W2110789683 creator A5020732815 @default.
• W2110789683 creator A5036785220 @default.
• W2110789683 creator A5037991950 @default.
• W2110789683 creator A5039710242 @default.
• W2110789683 creator A5039882839 @default.
• W2110789683 creator A5047485845 @default.
• W2110789683 creator A5062225206 @default.
• W2110789683 creator A5072691096 @default.
• W2110789683 creator A5074501620 @default.
• W2110789683 date "2013-09-01" @default.
• W2110789683 modified "2023-10-15" @default.
• W2110789683 title "AC1MMYR2, an Inhibitor of Dicer-Mediated Biogenesis of Oncomir miR-21, Reverses Epithelial–Mesenchymal Transition and Suppresses Tumor Growth and Progression" @default.
• W2110789683 cites W1566823022 @default.
• W2110789683 cites W1648301895 @default.
• W2110789683 cites W1946997080 @default.
• W2110789683 cites W1968008181 @default.
• W2110789683 cites W1976013341 @default.
• W2110789683 cites W1980920427 @default.
• W2110789683 cites W1988409793 @default.
• W2110789683 cites W1989015932 @default.
• W2110789683 cites W1990079648 @default.
• W2110789683 cites W1991443947 @default.
• W2110789683 cites W1992695694 @default.
• W2110789683 cites W1998990473 @default.
• W2110789683 cites W2000093333 @default.
• W2110789683 cites W2013842709 @default.
• W2110789683 cites W2016273963 @default.
• W2110789683 cites W2032563823 @default.
• W2110789683 cites W2034269086 @default.
• W2110789683 cites W2035213975 @default.
• W2110789683 cites W2049130046 @default.
• W2110789683 cites W2050079849 @default.
• W2110789683 cites W2058462008 @default.
• W2110789683 cites W2072269334 @default.
• W2110789683 cites W2086641174 @default.
• W2110789683 cites W2087527154 @default.
• W2110789683 cites W2087975583 @default.
• W2110789683 cites W2093464881 @default.
• W2110789683 cites W2102627944 @default.
• W2110789683 cites W2104312647 @default.
• W2110789683 cites W2106929712 @default.
• W2110789683 cites W2110362508 @default.
• W2110789683 cites W2110962672 @default.
• W2110789683 cites W2112738778 @default.
• W2110789683 cites W2114123948 @default.
• W2110789683 cites W2117692326 @default.
• W2110789683 cites W2128237118 @default.
• W2110789683 cites W2132094707 @default.
• W2110789683 cites W2137403619 @default.
• W2110789683 cites W2154589460 @default.
• W2110789683 cites W2156629568 @default.
• W2110789683 cites W2161161020 @default.
• W2110789683 cites W2165123465 @default.
• W2110789683 cites W2165437648 @default.
• W2110789683 cites W2165469857 @default.
• W2110789683 cites W2165764599 @default.
• W2110789683 cites W2166938936 @default.
• W2110789683 cites W2167715370 @default.
• W2110789683 cites W2170407810 @default.
• W2110789683 cites W2172083228 @default.
• W2110789683 doi "https://doi.org/10.1158/0008-5472.can-13-0280" @default.
• W2110789683 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23811941" @default.
• W2110789683 hasPublicationYear "2013" @default.
• W2110789683 type Work @default.
• W2110789683 sameAs 2110789683 @default.
• W2110789683 citedByCount "151" @default.
• W2110789683 countsByYear W21107896832013 @default.
• W2110789683 countsByYear W21107896832014 @default.
• W2110789683 countsByYear W21107896832015 @default.
• W2110789683 countsByYear W21107896832016 @default.
• W2110789683 countsByYear W21107896832017 @default.
• W2110789683 countsByYear W21107896832018 @default.
• W2110789683 countsByYear W21107896832019 @default.
• W2110789683 countsByYear W21107896832020 @default.
• W2110789683 countsByYear W21107896832021 @default.
• W2110789683 countsByYear W21107896832022 @default.
• W2110789683 countsByYear W21107896832023 @default.
• W2110789683 crossrefType "journal-article" @default.
• W2110789683 hasAuthorship W2110789683A5007814846 @default.
• W2110789683 hasAuthorship W2110789683A5016196534 @default.
• W2110789683 hasAuthorship W2110789683A5018122772 @default.
• W2110789683 hasAuthorship W2110789683A5020732815 @default.
• W2110789683 hasAuthorship W2110789683A5036785220 @default.
• W2110789683 hasAuthorship W2110789683A5037991950 @default.
• W2110789683 hasAuthorship W2110789683A5039710242 @default.
• W2110789683 hasAuthorship W2110789683A5039882839 @default.
• W2110789683 hasAuthorship W2110789683A5047485845 @default.
• W2110789683 hasAuthorship W2110789683A5062225206 @default.
• W2110789683 hasAuthorship W2110789683A5072691096 @default.
• W2110789683 hasAuthorship W2110789683A5074501620 @default.
• W2110789683 hasBestOaLocation W21107896832 @default.
• W2110789683 hasConcept C104317684 @default.
• W2110789683 hasConcept C121608353 @default.

• next