Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110797464> ?p ?o ?g. }
- W2110797464 endingPage "3989" @default.
- W2110797464 startingPage "3989" @default.
- W2110797464 abstract "Over the past 60 years, numerous medical strategies have been employed to overcome neoplasms. In fact, with the exception of lung, bronchial, and pancreatic cancers, the 5-year survival rate of most cancers currently exceeds 70%. However, the quality of life of patients during chemotherapy remains unsatisfactory despite the increase in survival rate. The side effects of current chemotherapies stem from poor target efficiency at tumor sites due to the uncontrolled biodistribution of anticancer agents (ie, conventional or current approved nanodrugs). This review discusses the effective physiochemical factors for determining biodistribution of nanocarriers and, ultimately, increasing tumor-targeting probability by avoiding the reticuloendothelial system. Second, stem cell-conjugated nanotherapeutics was addressed to maximize the tumor searching ability and to inhibit tumor growth. Lastly, physicochemical material properties of anticancer nanodrugs were discussed for targeting cellular organelles with modulation of drug-release time. A better understanding of suggested topics will increase the tumor-targeting ability of anticancer drugs and, ultimately, promote the quality of life of cancer patients during chemotherapy." @default.
- W2110797464 created "2016-06-24" @default.
- W2110797464 creator A5062491635 @default.
- W2110797464 creator A5084473082 @default.
- W2110797464 date "2015-06-01" @default.
- W2110797464 modified "2023-09-23" @default.
- W2110797464 title "Multiple cues on the physiochemical, mesenchymal, and intracellular trafficking interactions with nanocarriers to maximize tumor target efficiency" @default.
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