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- W2110801198 abstract "Abstract Peroxynitrite (ONOO − ) is a highly reactive species implicated in the pathology of numerous diseases and there is currently great interest in developing fluorescent probes that can selectively detect ONOO − in living cells. Herein, a polymeric micelle‐based and cell‐penetrating peptide‐coated fluorescent nanoprobe that incorporates ONOO − indicator dye and reference dye for the ratiometric detection and imaging of ONOO − has been developed. The nanoprobe effectively avoids the influences from enzymatic reaction and high‐concentration . OH and ClO − . The improved ONOO − selectivity of the nanoprobe is achieved by a delicate complementarity of properties between the nanomatrix and the embedded molecular probe (BzSe‐Cy). This nanoprobe also has other attractive properties, such as good water solubility, photostability, biocompatibility, and near‐infrared excitation and emission. Fluorescence imaging experiments by confocal microscopy show that this nanoprobe is capable of visualizing ONOO − produced in living cells and it exhibits very low toxicity and good membrane permeability. We anticipate that this technique will be a potential tool for the precise pathological understanding and diagnosis of ONOO − ‐related human diseases." @default.
- W2110801198 created "2016-06-24" @default.
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- W2110801198 date "2011-05-17" @default.
- W2110801198 modified "2023-10-18" @default.
- W2110801198 title "A Highly Selective, Cell-Permeable Fluorescent Nanoprobe for Ratiometric Detection and Imaging of Peroxynitrite in Living Cells" @default.
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- W2110801198 doi "https://doi.org/10.1002/chem.201100148" @default.
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