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- W2110831490 abstract "Homologous pairing establishes the foundation for accurate reductional segregation during meiosis I in sexual organisms. This Commentary summarizes recent progress in our understanding of homologous pairing in meiosis, and will focus on the characteristics and mechanisms of specialized chromosome sites, called pairing centers (PCs), in Caenorhabditis elegans and Drosophila melanogaster. In C. elegans, each chromosome contains a single PC that stabilizes chromosome pairing and initiates synapsis of homologous chromosomes. Specific zinc-finger proteins recruited to PCs link chromosomes to nuclear envelope proteins – and through them to the microtubule cytoskeleton – thereby stimulating chromosome movements in early prophase, which are thought to be important for homolog sorting. This mechanism appears to be a variant of the ‘telomere bouquet’ process, in which telomeres cluster on the nuclear envelope, connect chromosomes through nuclear envelope proteins to the cytoskeleton and lead chromosome movements that promote homologous synapsis. In Drosophila males, which undergo meiosis without recombination, pairing of the largely non-homologous X and Y chromosomes occurs at specific repetitive sequences in the ribosomal DNA. Although no other clear examples of PC-based pairing mechanisms have been described, there is evidence for special roles of telomeres and centromeres in aspects of chromosome pairing, synapsis and segregation; these roles are in some cases similar to those of PCs." @default.
- W2110831490 created "2016-06-24" @default.
- W2110831490 creator A5007572777 @default.
- W2110831490 creator A5024832875 @default.
- W2110831490 date "2011-06-15" @default.
- W2110831490 modified "2023-10-10" @default.
- W2110831490 title "Homologous pairing and the role of pairing centers in meiosis" @default.
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- W2110831490 doi "https://doi.org/10.1242/jcs.006387" @default.
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