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• W2110839885 abstract "The aims of current asthma treatment are to suppress airway inflammation and control symptoms, and corticosteroids maintain a commanding position in this role. Steroids effectively suppress inflammation in the majority of patients but have little impact on the natural history of this disease. In severe asthmatics, corticosteroids may have relatively less beneficial effects. Recent advances in understanding the inflammatory and immunological mechanisms of asthma have indicated many potential therapeutic avenues that may prevent or reverse abnormalities that underlie asthma. As the roles of effector cells, and of signalling and adhesion molecules are better understood, the opportunities to inhibit or prevent the inflammatory cascade have increased. In addition, there have been advances in the synthesis of proteins, monoclonal antibodies and new small molecule chemical entities, which may provide valuable flexibility in the therapeutic approach to asthma. The novel immunological approaches include the prevention of T-cell activation, attempts to influence the balance of T-helper cell (Th) populations to inhibit or prevent Th2-derived cytokine expression, and the inhibition or blockade of the downstream actions of these cytokines such as effects on immunoglobulin-E and eosinophils. These approaches provide broad as well as highly specific targeting, and also prospects for prevention and reversal of immunological and inflammatory abnormalities associated with asthma. Hopefully, the development of effective antiasthma agents with effects beyond those provided by current therapies coupled with lesser side-effects will further address the unmet needs of asthma." @default.
• W2110839885 created "2016-06-24" @default.
• W2110839885 creator A5054513704 @default.
• W2110839885 creator A5084933022 @default.
• W2110839885 date "2000-12-01" @default.
• W2110839885 modified "2023-09-26" @default.
• W2110839885 title "New immunological approaches and cytokine targetsin asthma and allergy" @default.
• W2110839885 cites W1485265843 @default.
• W2110839885 cites W1487602178 @default.
• W2110839885 cites W1499740654 @default.
• W2110839885 cites W1501778305 @default.
• W2110839885 cites W1502285375 @default.
• W2110839885 cites W1506899062 @default.
• W2110839885 cites W1510730676 @default.
• W2110839885 cites W1514549604 @default.
• W2110839885 cites W1518596541 @default.
• W2110839885 cites W1529664481 @default.
• W2110839885 cites W1533977973 @default.
• W2110839885 cites W1534597048 @default.
• W2110839885 cites W1536099164 @default.
• W2110839885 cites W1536259865 @default.
• W2110839885 cites W1544939802 @default.
• W2110839885 cites W1545898053 @default.
• W2110839885 cites W1545940824 @default.
• W2110839885 cites W1560264230 @default.
• W2110839885 cites W1570159316 @default.
• W2110839885 cites W1586162124 @default.
• W2110839885 cites W1595980407 @default.
• W2110839885 cites W1600785363 @default.
• W2110839885 cites W1601925808 @default.
• W2110839885 cites W1615320989 @default.
• W2110839885 cites W1798181153 @default.
• W2110839885 cites W1831514224 @default.
• W2110839885 cites W1846706131 @default.
• W2110839885 cites W1854728040 @default.
• W2110839885 cites W1892601834 @default.
• W2110839885 cites W1902360293 @default.
• W2110839885 cites W1910182345 @default.
• W2110839885 cites W1914519050 @default.
• W2110839885 cites W1921048215 @default.
• W2110839885 cites W1921708445 @default.
• W2110839885 cites W1924532031 @default.
• W2110839885 cites W1926036492 @default.
• W2110839885 cites W1926554700 @default.
• W2110839885 cites W1955666311 @default.
• W2110839885 cites W1964318104 @default.
• W2110839885 cites W1965263372 @default.
• W2110839885 cites W1965366343 @default.
• W2110839885 cites W1966279732 @default.
• W2110839885 cites W1966847012 @default.
• W2110839885 cites W1968074912 @default.
• W2110839885 cites W1973218579 @default.
• W2110839885 cites W1973575681 @default.
• W2110839885 cites W1974398640 @default.
• W2110839885 cites W1974464589 @default.
• W2110839885 cites W1976186260 @default.
• W2110839885 cites W1979670373 @default.
• W2110839885 cites W1980314964 @default.
• W2110839885 cites W1980359315 @default.
• W2110839885 cites W1981370277 @default.
• W2110839885 cites W1981772252 @default.
• W2110839885 cites W1982321149 @default.
• W2110839885 cites W1983094057 @default.
• W2110839885 cites W1983548833 @default.
• W2110839885 cites W1983795206 @default.
• W2110839885 cites W1988939115 @default.
• W2110839885 cites W1990470211 @default.
• W2110839885 cites W1990668161 @default.
• W2110839885 cites W1992878536 @default.
• W2110839885 cites W1993823557 @default.
• W2110839885 cites W1993986104 @default.
• W2110839885 cites W1994918682 @default.
• W2110839885 cites W1995393576 @default.
• W2110839885 cites W1995484947 @default.
• W2110839885 cites W1996222302 @default.
• W2110839885 cites W1997345461 @default.
• W2110839885 cites W1997453039 @default.
• W2110839885 cites W1998804177 @default.
• W2110839885 cites W1999097938 @default.
• W2110839885 cites W2002796983 @default.
• W2110839885 cites W2003195129 @default.
• W2110839885 cites W2005659566 @default.
• W2110839885 cites W2005743710 @default.
• W2110839885 cites W2006758118 @default.
• W2110839885 cites W2007210793 @default.
• W2110839885 cites W2007301712 @default.
• W2110839885 cites W2007705609 @default.
• W2110839885 cites W2011181815 @default.
• W2110839885 cites W2011611370 @default.
• W2110839885 cites W2011854432 @default.
• W2110839885 cites W2013334397 @default.
• W2110839885 cites W2013394968 @default.
• W2110839885 cites W2013667962 @default.
• W2110839885 cites W2016877516 @default.
• W2110839885 cites W2017680713 @default.
• W2110839885 cites W2021475285 @default.
• W2110839885 cites W2021771144 @default.
• W2110839885 cites W2022467740 @default.
• W2110839885 cites W2025463080 @default.
• W2110839885 cites W2025780723 @default.

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