FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110839957> ?p ?o ?g. }

• W2110839957 endingPage "67" @default.
• W2110839957 startingPage "59" @default.
• W2110839957 abstract "ABSTRACT Following acute infection, bovine herpesvirus 1 establishes latency in sensory neurons of trigeminal ganglia (TG). Reactivation from latency occurs periodically, resulting in the shedding of infectious virus. The latency-related (LR) RNA is abundantly expressed in TG of latently infected calves, and the expression of LR proteins is necessary for dexamethasone-induced reactivation from latency. Previously published studies also identified an alternatively spliced LR transcript which is abundantly expressed in TG at 7 days after infection and has the potential to encode a novel LR fusion protein. Seven days after infection is when extensive viral gene expression is extinguished in TG and latency is established, suggesting that LR gene products influence the establishment of latency. In this study, we used a bacterial two-hybrid assay to identify cellular proteins that interact with the novel LR fusion protein. The LR fusion protein interacts with two proteins that can induce apoptosis (Bid and Cdc42) and with CCAAT enhancer binding protein alpha (C/EBP-α). Additional studies confirmed that the LR fusion protein interacts with human or insect C/EBP-α. C/EBP-α protein expression is induced in TG neurons of infected calves and after dexamethasone-induced reactivation from latency. Wild-type C/EBP-α, but not a DNA binding mutant of C/EBP-α, enhances plaque formation in bovine cells. We hypothesize that interactions between the LR fusion protein and C/EBP-α promote the establishment of latency." @default.
• W2110839957 created "2016-06-24" @default.
• W2110839957 creator A5007389935 @default.
• W2110839957 creator A5012907839 @default.
• W2110839957 creator A5020518181 @default.
• W2110839957 creator A5022021074 @default.
• W2110839957 creator A5051057053 @default.
• W2110839957 creator A5082998599 @default.
• W2110839957 date "2007-01-01" @default.
• W2110839957 modified "2023-09-25" @default.
• W2110839957 title "A Protein Encoded by the Bovine Herpesvirus 1 Latency-Related Gene Interacts with Specific Cellular Regulatory Proteins, Including CCAAT Enhancer Binding Protein Alpha" @default.
• W2110839957 cites W1223737510 @default.
• W2110839957 cites W124976120 @default.
• W2110839957 cites W1497403334 @default.
• W2110839957 cites W1561945694 @default.
• W2110839957 cites W1595341613 @default.
• W2110839957 cites W1900123921 @default.
• W2110839957 cites W1911871984 @default.
• W2110839957 cites W1948099035 @default.
• W2110839957 cites W1964952212 @default.
• W2110839957 cites W1967344468 @default.
• W2110839957 cites W1970587959 @default.
• W2110839957 cites W1971106880 @default.
• W2110839957 cites W1986184556 @default.
• W2110839957 cites W2001105637 @default.
• W2110839957 cites W2002371933 @default.
• W2110839957 cites W2006981341 @default.
• W2110839957 cites W2022139382 @default.
• W2110839957 cites W2037781454 @default.
• W2110839957 cites W2038671251 @default.
• W2110839957 cites W2047356236 @default.
• W2110839957 cites W2062853648 @default.
• W2110839957 cites W2066183774 @default.
• W2110839957 cites W2078496269 @default.
• W2110839957 cites W2082781045 @default.
• W2110839957 cites W2084237034 @default.
• W2110839957 cites W2087927757 @default.
• W2110839957 cites W2090389062 @default.
• W2110839957 cites W2091349362 @default.
• W2110839957 cites W2096414918 @default.
• W2110839957 cites W2098609440 @default.
• W2110839957 cites W2101269168 @default.
• W2110839957 cites W2104560888 @default.
• W2110839957 cites W2115820633 @default.
• W2110839957 cites W2117228677 @default.
• W2110839957 cites W2121955382 @default.
• W2110839957 cites W2124968337 @default.
• W2110839957 cites W2125182279 @default.
• W2110839957 cites W2125647762 @default.
• W2110839957 cites W2126376871 @default.
• W2110839957 cites W2126518367 @default.
• W2110839957 cites W2127789417 @default.
• W2110839957 cites W2128392947 @default.
• W2110839957 cites W2128442288 @default.
• W2110839957 cites W2129545722 @default.
• W2110839957 cites W2129567429 @default.
• W2110839957 cites W2129605913 @default.
• W2110839957 cites W2132581604 @default.
• W2110839957 cites W2134812217 @default.
• W2110839957 cites W2134910761 @default.
• W2110839957 cites W2135031647 @default.
• W2110839957 cites W2138105707 @default.
• W2110839957 cites W2138845576 @default.
• W2110839957 cites W2140635480 @default.
• W2110839957 cites W2142234363 @default.
• W2110839957 cites W2143544250 @default.
• W2110839957 cites W2150360161 @default.
• W2110839957 cites W2154922320 @default.
• W2110839957 cites W2154969815 @default.
• W2110839957 cites W2163837394 @default.
• W2110839957 cites W2166219468 @default.
• W2110839957 cites W2168979611 @default.
• W2110839957 cites W2206590192 @default.
• W2110839957 cites W2240099981 @default.
• W2110839957 cites W2321137366 @default.
• W2110839957 cites W2409107929 @default.
• W2110839957 cites W2466542403 @default.
• W2110839957 cites W4252526484 @default.
• W2110839957 cites W993271046 @default.
• W2110839957 doi "https://doi.org/10.1128/jvi.01171-06" @default.
• W2110839957 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1797275" @default.
• W2110839957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16987965" @default.
• W2110839957 hasPublicationYear "2007" @default.
• W2110839957 type Work @default.
• W2110839957 sameAs 2110839957 @default.
• W2110839957 citedByCount "37" @default.
• W2110839957 countsByYear W21108399572012 @default.
• W2110839957 countsByYear W21108399572013 @default.
• W2110839957 countsByYear W21108399572014 @default.
• W2110839957 countsByYear W21108399572015 @default.
• W2110839957 countsByYear W21108399572016 @default.
• W2110839957 countsByYear W21108399572017 @default.
• W2110839957 countsByYear W21108399572018 @default.
• W2110839957 countsByYear W21108399572019 @default.
• W2110839957 countsByYear W21108399572020 @default.
• W2110839957 countsByYear W21108399572021 @default.
• W2110839957 countsByYear W21108399572023 @default.
• W2110839957 crossrefType "journal-article" @default.

• next