Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110846335> ?p ?o ?g. }
- W2110846335 endingPage "10807" @default.
- W2110846335 startingPage "10800" @default.
- W2110846335 abstract "ABSTRACT The pathogenicity of individual rabies virus strains appears to correlate inversely with the extent of apoptotic cell death they induce and with the expression of rabies virus glycoprotein, a major inducer of an antiviral immune response. To determine whether the induction of apoptosis by rabies virus contributes to a decreased pathogenicity by stimulating antiviral immunity, we have analyzed these parameters in tissue cultures and in mice infected with a recombinant rabies virus construct that expresses the proapoptotic protein cytochrome c . The extent of apoptosis was strongly increased in primary neuron cultures infected with the recombinant virus carrying the active cytochrome c gene [SPBN-Cyto c (+)], compared with cells infected with the recombinant virus containing the inactive cytochrome c gene [SPBN-Cyto c (−)]. Mortality in mice infected intranasally with SPBN-Cyto c (+) was substantially lower than in SPBN-Cyto c (−)-infected mice. Furthermore, virus-neutralizing antibody (VNA) titers were significantly higher in mice immunized with SPBN-Cyto c (+) at the same dose. The VNA titers induced by these recombinant viruses paralleled their protective activities against a lethal rabies virus challenge infection, with SPBN-Cyto c (+) revealing an effective dose 20 times lower than that of SPBN-Cyto c (−). The strong increase in immunogenicity, coupled with the marked reduction in pathogenicity, identifies the SPBN-Cyto c (+) construct as a candidate for a live rabies virus vaccine." @default.
- W2110846335 created "2016-06-24" @default.
- W2110846335 creator A5023081527 @default.
- W2110846335 creator A5055446611 @default.
- W2110846335 creator A5061015062 @default.
- W2110846335 creator A5061798289 @default.
- W2110846335 creator A5074172437 @default.
- W2110846335 creator A5083512969 @default.
- W2110846335 creator A5083679881 @default.
- W2110846335 creator A5088083152 @default.
- W2110846335 date "2001-11-15" @default.
- W2110846335 modified "2023-09-24" @default.
- W2110846335 title "Overexpression of Cytochrome<i>c</i>by a Recombinant Rabies Virus Attenuates Pathogenicity and Enhances Antiviral Immunity" @default.
- W2110846335 cites W104778642 @default.
- W2110846335 cites W122655610 @default.
- W2110846335 cites W1497563480 @default.
- W2110846335 cites W1596938308 @default.
- W2110846335 cites W1808945270 @default.
- W2110846335 cites W189150728 @default.
- W2110846335 cites W1902202060 @default.
- W2110846335 cites W1930745477 @default.
- W2110846335 cites W1931029669 @default.
- W2110846335 cites W1966516021 @default.
- W2110846335 cites W1988641656 @default.
- W2110846335 cites W2000693331 @default.
- W2110846335 cites W2009031675 @default.
- W2110846335 cites W2022210556 @default.
- W2110846335 cites W2049570385 @default.
- W2110846335 cites W2064588452 @default.
- W2110846335 cites W2069428724 @default.
- W2110846335 cites W2096585125 @default.
- W2110846335 cites W2106755615 @default.
- W2110846335 cites W2110029891 @default.
- W2110846335 cites W2115130178 @default.
- W2110846335 cites W2122231405 @default.
- W2110846335 cites W2126678018 @default.
- W2110846335 cites W2138270910 @default.
- W2110846335 cites W2186955961 @default.
- W2110846335 cites W2291097611 @default.
- W2110846335 cites W2312581883 @default.
- W2110846335 cites W2411303243 @default.
- W2110846335 cites W2419491592 @default.
- W2110846335 cites W2419699661 @default.
- W2110846335 cites W4313331874 @default.
- W2110846335 cites W67584196 @default.
- W2110846335 doi "https://doi.org/10.1128/jvi.75.22.10800-10807.2001" @default.
- W2110846335 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/114661" @default.
- W2110846335 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11602721" @default.
- W2110846335 hasPublicationYear "2001" @default.
- W2110846335 type Work @default.
- W2110846335 sameAs 2110846335 @default.
- W2110846335 citedByCount "58" @default.
- W2110846335 countsByYear W21108463352012 @default.
- W2110846335 countsByYear W21108463352013 @default.
- W2110846335 countsByYear W21108463352014 @default.
- W2110846335 countsByYear W21108463352015 @default.
- W2110846335 countsByYear W21108463352016 @default.
- W2110846335 countsByYear W21108463352017 @default.
- W2110846335 countsByYear W21108463352019 @default.
- W2110846335 countsByYear W21108463352020 @default.
- W2110846335 countsByYear W21108463352023 @default.
- W2110846335 crossrefType "journal-article" @default.
- W2110846335 hasAuthorship W2110846335A5023081527 @default.
- W2110846335 hasAuthorship W2110846335A5055446611 @default.
- W2110846335 hasAuthorship W2110846335A5061015062 @default.
- W2110846335 hasAuthorship W2110846335A5061798289 @default.
- W2110846335 hasAuthorship W2110846335A5074172437 @default.
- W2110846335 hasAuthorship W2110846335A5083512969 @default.
- W2110846335 hasAuthorship W2110846335A5083679881 @default.
- W2110846335 hasAuthorship W2110846335A5088083152 @default.
- W2110846335 hasBestOaLocation W21108463352 @default.
- W2110846335 hasConcept C104317684 @default.
- W2110846335 hasConcept C159047783 @default.
- W2110846335 hasConcept C203014093 @default.
- W2110846335 hasConcept C2522874641 @default.
- W2110846335 hasConcept C2776849203 @default.
- W2110846335 hasConcept C2777961786 @default.
- W2110846335 hasConcept C2777974785 @default.
- W2110846335 hasConcept C2779811178 @default.
- W2110846335 hasConcept C2780355102 @default.
- W2110846335 hasConcept C2780727368 @default.
- W2110846335 hasConcept C2780813555 @default.
- W2110846335 hasConcept C2780868878 @default.
- W2110846335 hasConcept C32611913 @default.
- W2110846335 hasConcept C39060996 @default.
- W2110846335 hasConcept C40767141 @default.
- W2110846335 hasConcept C55493867 @default.
- W2110846335 hasConcept C86803240 @default.
- W2110846335 hasConcept C8891405 @default.
- W2110846335 hasConcept C89423630 @default.
- W2110846335 hasConceptScore W2110846335C104317684 @default.
- W2110846335 hasConceptScore W2110846335C159047783 @default.
- W2110846335 hasConceptScore W2110846335C203014093 @default.
- W2110846335 hasConceptScore W2110846335C2522874641 @default.
- W2110846335 hasConceptScore W2110846335C2776849203 @default.
- W2110846335 hasConceptScore W2110846335C2777961786 @default.
- W2110846335 hasConceptScore W2110846335C2777974785 @default.
- W2110846335 hasConceptScore W2110846335C2779811178 @default.