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- W2110852907 abstract "A series of novel arylacetamides were designed to further explore the GK binding property at the aminothiazole C5 position. The C5-amide substituted aminothiazoles 7a–f generally displayed decreased potency, whereas most of the C5-triazole substituted aminothiazoles retained good GK potency. Triazole 15 with a hydroxyethyl side chain was the most potent among the current series possessing an EC50 value of 0.18 μM. Its R-enantiomerR-15 showed similar potency (0.22 μM) that deserves for further evaluation." @default.
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- W2110852907 date "2011-01-01" @default.
- W2110852907 modified "2023-09-27" @default.
- W2110852907 title "N-(5-substituted thiazol-2-yl)-2-aryl-3-(tetrahydro-2H-pyran-4-yl) propanamides as glucokinase activators" @default.
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- W2110852907 doi "https://doi.org/10.1039/c1md00002k" @default.
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